Adequate Duration of Medical Therapy for Koreans with Graves’ Disease
한국인에게서 그레이브스병 약물치료의 적정기간
이, 형숙; 이, 동훈; 정, 희선; 이, 종우; 김, 정은; 신, 승수; 정, 윤석; 이, 관우; 김, 현만
Journal of Korean Society of Endocrinology, 18(1):24-31, 2003
Journal of Korean Society of Endocrinology; 대한내분비학회지
Background: Graves’ disease is an organ specific autoimmune disease. Three kinds of therapeutic modalities (antithyroid drugs, ablation with radioactive iodine and subtotal thyroidectomy) are frequently performed for the management of this disease. The most popular therapeutic policy for the disease in Korea is antithyroid treatment. We analyzed and compared the remission rates of all three modalities for Graves’ disease, and evaluated the antithyroid modality to determine the correct duration of treatment.
Subjects & Methods: The medical records of 205 patients with Graves’ disease were reviewed. For the evaluation of the antithyroid modality medical treatment, antithyroid drugs were administered for more than 1 year. The prognostic factors associated with remission were analysed by means of an ROC curve.
Results: 1) Of the 205 patients, proportions that received medical therapy, subtotal thyroidectomy and radioiodine therapy were 83.0, 14.1 and 2.9%, respectively.
2) The remission rates of the medial therapy, surgery and radioiodine therapy were 60.0, 96.5 and 83.0%, respectively.
3) The remission rate of the medical therapy was associated with the duration of medication and TBII activity. The determined proper duration for the antithyroid treatment was 26 months from the ROC curve analysis.
Conclusion: The above results suggest that the proper duration of antithyroid treatment for Graves’ disease is 26 months, after which time the subtotal thyroidectomy or radioiodine therapy should be considered if the disease has not remitted.
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