Cited 0 times in Scipus Cited Count

Adequate Duration of Medical Therapy for Koreans with Graves' Disease

Other Title
한국인에게서 그레이브스병 약물치료의 적정기간
Authors
이, 형숙 | 이, 동훈 | 정, 희선 | 이, 종우 | 김, 정은 | 신, 승수  | 정, 윤석  | 이, 관우  | 김, 현만
Citation
Journal of Korean Society of Endocrinology, 18(1). : 24-31, 2003
Journal Title
Journal of Korean Society of Endocrinology
ISSN
1015-6380
Abstract
BACKGROUND: Graves' disease is an organ specific autoimmune disease. Three kinds of therapeutic modalities(antithyroid drugs, ablation with radioactive iodine and subtotal thyroidectomy) are frequently performed for the management of this disease. The most popular therapeutic policy for the disease in Korea is antithyroid treatment. We analysed and compared the remission rates of all three modalities for Graves' disease, and evaluated the antithyroid modality to determine the correct duration of treatment.
SUBJECTS AND METHODS: The medical records of 205 patients with Graves' disease were reviewed. For the evaluation of the antithyroid modality medical treatment, antithyroid drugs were administered for more than 1 year. The prognostic factors associated with remission were analysed by means of an ROC curve.
RESULTS: 1) Of the 205 patients, proportions that received medical therapy, subtotal thyroidectomy and radioiodine therapy were 83.0, 14.1 and 2.9%, respectively. 2) The remission rates of the medical therapy, surgery and radioiodine therapy were 60.0, 96.5 and 83.0%, respectively. 3) The remission rate of the medical therapy was associated with the duration of medication and TBII activity. The determined proper duration for the antithyroid treatment was 26 months from the ROC curve analysis.
CONCLUSION: The above results suggest that the proper duration of antithyroid treatment for Graves' disease is 26 months, after which time the subtotal thyroidectomy or radioiodine therapy should be considered if the disease has not remitted.
Keywords

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Ajou Authors
김, 현만  |  신, 승수  |  이, 관우  |  정, 윤석
Full Text Link
Files in This Item:
Journal of Korean Society of Endocrinology_18(1)_24-31.pdfDownload
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse