Cytokeratin Immunohistochemistry of Acquired Cholesteatoma in Middle Ear
중이진주종상피의 사이토케라틴에 관한 면역조직화학적 연구
박, 기현; 전, 영명; 박, 홍준
Taehan Ibi Inhukwa Hakhoe chi, 37(1):5-13, 1994
Taehan Ibi Inhukwa Hakhoe chi; Journal of the Korean Otolaryngological Society; 대한이비인후과학회지
Cholesteatoma matrix, ear canal skin, postauricular skin, postauricular skin, and middle ear surgery, and immunohistochemical technique was used to localize cytokeratin patterns of these tissues. In this study, we investigated differentiation of
different epitheliums using 5 monoclonal anti-epithelial keratin antibodies(AE) : AE-1, AE-2, AE-3, AE-5, AE-8. Several differences of cytokeratin patterns were observed between cholesteatoma matrix and postauricular skin as well as between
cholesteatoma and middle ear mucosa. However, similarity of cytoderatin patterns was observed between cholesteatoma matrix and ear canal skin. These findings support the skin type epithelial origin of cholesteatoma matrix and strongly favor the
imigration theory in the pathogenesis of cholesteatoma.
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