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Cytokeratin Immunohistochemistry of open Cavity Mastoidectomized Skin

Other Title
유양동삭개술후 개방공동피부의 사이토케라틴에 대한 연구
박, 기현; 전, 영명; 박, 홍준
Taehan Ibi Inhukwa Hakhoe chi, 39(2):185-191, 1996
Journal Title
Taehan Ibi Inhukwa Hakhoe chi; Journal of the Korean Otolaryngological Society; 대한이비인후과학회지
Cavity problem which can develop after an open cavity mastoidectomy have received much attention in the field of otology. Such cavity problem occurs when squamous debris accumulates in the newly formed cavity. Recently, the morphology of this


formed skin in the open mastoidectomized cavity was investigated to compare with that of the cholesteatoma matrix.

The aim of this study was to compare the cytokratin pattern of the cavity skin with that of middle ear cholesteatoma and canal skin, and to search the pathogenesis of cholesteatoma. In this study, we investigated cytokeratin expression of the


skin, cholesteatoma matrix, postauricular skin, middle ear epithelium and ear canal skin, using an immunohistochemical technique with five subtypes of monoclonal anti-epithelial keratin.

Similarity of cytokeratin patterns was observed among cavity skin, middle ear cholestetoma and ear canal ski. These findings support the skin type epithelial orgin of cholestatoma and strongly favor the immigration theory in the genesis of

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Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
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