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Cytokeratin Expressions of Induced Cholesteatoma in Gerbil

Other Title
실험적 진주종의 사이토케라틴 발현양상
박, 기현; 전, 영명; 박, 홍준
Taehan Ibi Inhukwa Hakhoe chi, 39(5):747-753, 1996
Journal Title
Taehan Ibi Inhukwa Hakhoe chi; Journal of the Korean Otolaryngological Society; 대한이비인후과학회지
Cholesteatoma is characterized by the presence of a keratinizing epithelium in the middle ear. The accumulation of desquamous epithelial cells appears to be a crucial factor in the pathogenesis of the middle ear chlesteatoma. The accumulation of


keratin debris is due to the migration, proliferation, and differentiation of basal keratinocytes.

In the present study, we investigated the expression of specific cytokeratins in the experimental cholesteatoma in gerbil to determine whether any difference of differentiation and proliferation between cholesteatoma and normal skin using several

specific cytokeratin.

Cytokeratin expression patterns of induced cholesteatoma and deep meatal skin were characterized ty the presence of hyperproliferative charateristics and some atypical variations. These suggest that extensive accumulation of keratinous mass in


meatus may changes in cellualr differentiation and proliferation.
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Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
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