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Immunohistochemical Study of Thrombomodulin in Experimental Cholesteatoma

Other Title
실험적으로 유도된 중이 진주종에서 TM (Thrombomodulin)의 발현에 대한 면역조직화학적 연구
박, 기현; 박, 홍준; 이, 진석; 엄, 주현
Taehan Ibi Inhukwa Hakhoe chi, 42(11):1349-1352, 1999
Journal Title
Taehan Ibi Inhukwa Hakhoe chi; Journal of the Korean Otolaryngological Society; 대한이비인후과학회지
Background and Objectives : The hyperproliferative character of human cholesteatoma epithelium was

confirmed through various hyperproliferation associated antibody expressions. Among the various

approaches for evaluating proliferative activity, thrombomodulin (TM) is a cell surface glycoprotein which

forms a high affinity non-covalent complex with thrombin and is a differentiation marker for spinous

layer keratinocytes. Several animal models have been introduced to study cholesteatoma pathogenesis,

among which canal ligation model using Mongolian gerbils is of much interest, because it can potentially

provide information on cell differentiation and proliferation of cholesteatoma. In this study, we investigated

the hyperproliferative characteristics of canal ligation cholesteatoma by comparing deep meatal skin and

retroauricular skin. Another purpose of this study was to provide the morphological basis for further

animal studies concerning cholesteatoma pathogenesis.

Materials and Method : Using immunohistochemical technique with anti-monoclonal antibody, we

investigated TM expression in the canal ligation cholesteatoma, deep meatal skin and retroauricular skin

of Mongolian gerbil.

Results : Experimental cholesteatoma induced by canal ligation and deep meatal skin showed TM

expression especially in the suprabasal layers. TM expression of experimental cholesteatoma is much more

intense than that of deep meatal skin.

Conclusion : Experimental cholesteatoma revealed an altered differentiation in suprabasal layer, suggesting

that this animal model can be used for further study in the epithelial differentiation and proliferation of

Immunohistochemical studyThrombomodulinExperimental cholesteatoma
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Journal Papers > School of Medicine / Graduate School of Medicine > Otolaryngology
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