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The clinical efficacy of the low dose aspirin and corticosteroid treatment in patients with endometriosis who underwent in - vitro fertilization and embryo transfer ( IVF-ET )

Other Title
자궁내막증 환자의 체외수정시술시 저용량 aspirin 과 corticosteroid 치료의 효용성에 관한 연구
Authors
김, 영아; 김, 미란; 황, 경주; 윤, 종혁; 서, 성석; 유, 희석
Citation
Taehan Sanbuinkwa Hakhoe chapchi, 45(3):431-437, 2002
Journal Title
Taehan Sanbuinkwa Hakhoe chapchi; Korean journal of obstetrics and gynecology; 대한산부인과학회잡지
ISSN
0494-4755
Abstract
Objective: To investigate the efficacy of low-dose aspirin and corticosteroid in IVF-ET patients with endometriosis. Materials and Methods: 45 infertile patients with endometriosis underwent 59 consecutive IVF-ET cycles. In the treatment group, 18 patients (23 cycles)underwent controlled ovarian hyperstimulation (COH) and received daily doses of 80 mg of aspirin and 15 mg of prednisone, startingon 3rd day of COH. In the control group, 27 patients (36 cycles)underwent COH without treatment. We analyzed the clinical characteristics, fertilization rates, good quality embryo ratio and pregnancy rates Results: There was no difference between groups in clinical characteristics (mean age, parity, LH, FSH, estradiol, progesterone), fertilization rates, and good embryo ratio. However, implantation rates were significantly different (29.81%vs.11.06%,p=0.019). Furthermore, hCG positive rates (60.89%vs.41.67%), clinical pregnancy rates (56.52%vs.33.33%), and on going pregnancy rates (>20weeks)(47.83%vs.27.78%) were increased in the study group compared to the control group. Conclusions: Combined treatment of low dose aspirin and prednisone improved pregnancy rates and implantation rates in IVF-ET patients with endometriosis. This results confirm the hypothesis that autoantibodies subsequently react with endometrial antigen leading to implantation failure and that we need to further research to the relationship of endometriosis with the immunologic aspect of implantation.
Keywords
EndometriosisAutoantibodyLow dose aspirinCorticosteroid
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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