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Postoperative adjuvant CCRT ( concurrentchemoradiotherapy ) for selected early stage cervical cancer patients following radical hysterectomy and pelvic lymph node dissection

Other Title
초기 자궁경부암 근치적자궁적출술 후 치료실패 고위험 환자군에서 보조적 항암화학방사선요법의 역할
Authors
김, 영아; 유, 희석; 전, 미선; 장, 기홍; 박, 영한; 오, 기석
Citation
Taehan Sanbuinkwa Hakhoe chapchi, 43(10):1725-1730, 2000
Journal Title
Taehan Sanbuinkwa Hakhoe chapchi; Korean journal of obstetrics and gynecology; 대한산부인과학회잡지
ISSN
0494-4755
Abstract
Objective : The purpose of this study was to evaluate the recurrence and survival rates after adjuvant concurrent chemoradiotherapy in high risk early cervical cancer(stage IA2, IB, IIA) patients treated by radical hysterectomy and pelvic lymphadenectomy(GOG #109 porotocols). Methods : We reviewed the charts of 63 patients who underwent radical abdominal hysterectomy and pelvic lymphadenectomy at Ajou University Hospital from July, 1994 to June, 1997 for early cervical cancer(stage IA2, IB, IIA). Concurrent chemoradiotherapy(CCRT) was performed in 15 patients with high risk factors such as positive pelvic lymph nodes, positive parametrial involvement, or positive surgical margins. Chemotherapy consisted of cisplatin(75mg/m2 on day 1) and 5-FU (1000mg/m2 on day 2-5) for 4 cycles every 4 weeks beginning 2 to 3 weeks after operation. The patients started pelvic radiotherapy with 2nd and 3rd cycle of chemotherapy concurrently. We compared the recurrence rate and survival rate with 48 patients who received no adjuvant therapy after radical hysterectomy and pelvic lymphadenectomy for early stage cervical cancer with or without risk factors. The mean follow up period was 37.3 months( range: 24- 51months).Results : Three of 63 patients(4.8%) had recurrent disease, all of whom didn't receive any adjuvant treatment postoperatively. There were no recurrence in patients with CCRT(0/15). However, all patients were alive until last follow up.Conclusion : This study shows excellent local control and relapse-free survival rates in the high-risk cervical cancer patients after CCRT which is similar results seen in control group. Postoperative adjuvant therapy, GOG #109, seems to be effective in high risk patients with good local control and survival rate. But due to small size sample and short duration of follow up, further follow up of a large number of patients is necessary.
Keywords
Adjuvant concurrent chemoradiotherapyPostoperative high risk groupEarly cervical cancer
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Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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