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Expression pattern of progesterone receptor, integrinβ₃, cyclooxygenase-2 (COX-2) in human endometrium of patient with the disease related implantation.

Other Title
착상관련 질환 환자의 자궁내막에 있어서 프로게스테론 수용체, integrinβ₃, cyclooxygenase-2(COX-2)의 발현 양상
Authors
이, 준서; 박, 동욱; 권, 혁찬; 김, 미란; 황, 경주; 주, 희재; 조, 동재; 김, 세광; 오, 기석
Citation
Taehan Sanbuinkwa Hakhoe chapchi, 43(6):961-967, 2000
Journal Title
Taehan Sanbuinkwa Hakhoe chapchi; Korean journal of obstetrics and gynecology; 대한산부인과학회잡지
ISSN
0494-4755
Abstract
Objective : We compared the expression pattern of progesterone receptor, integrin 3, cyclooxygenase-2 (COX-2) in in-phased endomerium of patient with the disease related implantation and control group, and tried to confirm the clinical efficacy of the immunohistochemical markers for discrimination of occult uterine receptivity defect in in-phase endometrium.Study design : Endometrial tissues were obtained from 60 women with normal (group 1; n = 20), uterine synechiae (group 2; n = 15), and endometriosis (group 3; n = 25). On 7 ∼ 8 days after ovulation (POD 7 ∼ 8), sex hormone levels were measured and immunohistochemical staining of PR, integrin 3, and COX-2 expression were performed. Results : PR was decreased in the group 2 and increased in the group 3 comparing with the group 1. integrin 3 expression was significantly decreased in the group 2 and 3. COX-2 expression was significantly decreased in the group 2. But, in the group 3, COX-2 expression was slightly increased in glandular epithelial cells, and significantly increased in stromal cells. Conclusions : In-phase biopsies from patients with endometriosis and uterine synechiae showed different expression pattern of integrin 3, COX-2, and PR compared to the control. The aberrant expression of immunohistochemical markers be associated with occult uterine receptivity defect and produce the useful diagnostic method.
Keywords
PRintegrin β₃COX-2endometriosisuterine synechiae
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Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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