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Prenatal Cytogenetic Diagnosis with Fetal Ascitic Fluid as a Rapid Chromosome Analysis

Other Title
산전 세포유전학적 진단에 있어서 태아 복수를 이용한 빠른 염색체 검사
양, 정인; 오, 기석; 김, 행수; 안, 은주; 심, 재선
Taehan Sanbuinkwa Hakhoe chapchi, 41(12):2997-3000, 1998
Journal Title
Taehan Sanbuinkwa Hakhoe chapchi; Korean journal of obstetrics and gynecology; 대한산부인과학회잡지
Objective: The goal of this study is to determine the efficacy of rapid karyotyping from fetal ascitic fluid. Methods: In three cases of isolated fetal ascites diagnosed by prenatal ultrasonography, ultrasound guided fetal paracentesis and amniocentesis were performed and successfully obtained. Fetal karyotyping in each case at 29, 30 and 32 weeks gestation using modified lymphocyte culture method was conducted. Results: The chromosomal analysis was successful within 72 hours and abnormalities were detected in two cases and revealed trisomy 21 in each case. Our study demonstrated that the majority distribution of white blood cells was lymphocytes which ranged from 2.1 * 10(6) cells/ml to 3.7 * 10(6) cells/ml and the cell density for culture was at least than 0.35 * 10(6) cells/ml. Conclusion: The use of ascitic fluid as a cell source to achieve rapid fetal karyotyping can be valuable when cordocenteis or amniocentesis would be technically more difficult, or when rapid result is required for planning of perinatal management at late second or third trimester gestational age.
Fetal ascitesRapid fetal karyotyping
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Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
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