Cited 0 times in Scipus Cited Count

Tissue-Engineered Human Neocartilage Formation Using Human Adult Auricular Cell Line

Other Title
사람 귀 연골 세포주와 조직공학술을 이용한 신생 연골의 재생
Authors
정, 재호  | 김, 승업  | 박, 병윤 | 박, 명철  | 임, 현이  | 이, 명애  | 홍, 현석
Citation
Journal of the Korean Society of Plastic and Reconstructive Surgeons, 30(5). : 639-647, 2003
Journal Title
Journal of the Korean Society of Plastic and Reconstructive Surgeons
ISSN
1015-6402
Abstract
The purpose of these studies was an establishment of human auricular chondrocyte cell line using retrovirus mediated v-myc transfer, characterizing the human auricular chondrocyte cell line by type 11 collagen mRNA expression and transplantation of human auricular cell line into immunological incompetent nude mice to establish neocartilage formation. Also, I evaluated the growth rate of chondrocyte cell line to measure the cellular proliferative potency. I have established the human auricular chondrocyte cell line integrated v-myc and confirmed by v-myc transduced Myc protein expression by immunohistochemistry and immunoblotting study. And, growth rate of established human auricular chondrocyte cell line increased 4 folds times faster than primarily cultured human auricular chondrocyte. The established human auricular chondrocyte had type II collagen mRNA up to 8 months in monolayer culture. And we observed formation of neocartilage on the back of nude mice using chondrocyte cell linelfibrin glue polymer at 12 weeks transplantation.
Keywords

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Plastic & Reconstructive Surgery
Journal Papers > Research Organization > Brain Disease Research Center
Journal Papers > School of Medicine / Graduate School of Medicine > Brain Science
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
Ajou Authors
김, 승업  |  박, 명철  |  이, 명애  |  임, 현이  |  정, 재호  |  홍, 현석
Full Text Link
Files in This Item:
There are no files associated with this item.
Export

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse