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Clinical Significance of Erosive and/or Small Ulcerative Lesions in the Colon and Terminal Ileum: Short-term Follow-up Study.

Other Title
대장 및 말단회장에서 발생한 미란 혹은 작은 궤양 병변의 임상 의의 -단기간의 추적관찰 연구-
김, 도현 | 이, 광재 | 김, 영배 | 이, 은희 | 송, 영주 | 김, 진홍 | 함, 기백 | 조, 성원
The Korean journal of gastroenterology, 44(6). : 321-327, 2004
Journal Title
The Korean journal of gastroenterology
BACKGROUND/AIMS: Various etiologies and diseases may be related to erosions and/or small ulcers without gross inflammatory changes in the surrounding mucosa found in the colon and terminal ileum during colonoscopy. However, studies on follow-up of these lesions are rare. Thus, we investigated the clinical significance of these lesions and their characteristics helpful for differential diagnosis.

METHODS: We reviewed the data of 183 patients with colonoscopically observed erosive or small ulcerative lesions (<2 cm), and analyzed them according to the location, number, and size of lesions, histopathologic findings, chief complaints, laboratory findings, changes of symptoms, and changes in lesions during 4-12 week follow-up period.

RESULTS: Histopathologic findings of these lesions included acute nonspecific inflammation, chronic nonspecific inflammation, Crohn´s disease, tuberculous colitis, ischemic colitis, Behcet´s disease, cytomegalovirus infection, eosinophilic colitis, ulcerative colitis or pseudomembranous colitis, but most of them were nonspecific (84%). In patients with nonspecific inflammation, histopathologic findings, symptoms, location and multiplicity of the lesions were not prognostic factors for the persistency of symptoms and lesions during follow-up period. Two patients with acute inflammation, who showed no improvement in symptoms and lesions, were later diagnosed as Crohn´s disease.

CONCLUSIONS: Erosive or small ulcerative lesions without macroscopic inflammatory changes in the surrounding mucosa during colonoscopy, are mainly nonspecific. However, careful follow-up is required when the symptoms and/or lesions are not improved

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Journal Papers > School of Medicine / Graduate School of Medicine > Unclassified
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