Neurotrophins and IGFs Attenuated Haloperidol-Induced Neuronal Apoptosis in Mouse Cortical Cell Cultures
할로페리돌로 유도한 신경세포 고사에 대한 신경성장인자 및 인슐린 유사 성장인자의 억제 효과
강, 효정; 강, 지윤; 곽, 병주; 정, 영기; 노, 재성
Journal of Korean Neuropsychiatric Association, 39(5):920-927, 2000
Journal of Korean Neuropsychiatric Association; 신경정신의학
Objectives : We examined the effects of neurotrophins and insulin-like growth factors on cell death induced by haloperidol, a typical anti-psychotic agent.
Method : Neocortices from 14- or 15-daysold fetal mice for neuron-glia co-cultures
were used for this experiment.
Results : Twenty-four hours treatment of mouse cortical cell cultures with 30 M
haloperidol-induced wide spread neuronal apoptosis characterized by cell body shrinkage, DNA fragmentation and condensation. concurrent treatment with growth factors, BDNF, NT4/5, IGF-Ⅰ and IGE-Ⅱ, protect the neurons from the haloperidol-induced neuronal apoptosis(HINA) in a dose dependent manner(10-100 ㎎/㎖).
Conclusion : The present study suggests the possibility that haloperidol toxicity can
be hampered with growth factors. Further study about the mechanism underlying the
protective capacity of the growth factors on HINA may lead to the development of the
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