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A Case of Creutzfeldt-Jacob Disease

Other Title
Creutzfeldt-Jacob병 1례
홍, 승철; 한, 진희; 정, 종현; 김, 소양; 허, 균; 이, 성필
Journal of Korean Neuropsychiatric Association, 37(1):180-185, 1998
Journal Title
Journal of Korean Neuropsychiatric Association; 신경정신의학
We report a case of Creutzfeldt-Jacob disease and review the relevant literatures. This 56-year-old male patient was admitted to our hospital with a history of rapidly

progressing cognitive dysfunction, visual disturbance, gait disturbance, weakness,

involuntary movement of lower extremities, and the symptoms of delirium.

On mental status examination, he showed psychomotor retardation, speech disturbance,

perseveration, disorientation, impairement of short-term and long-term memory, and

inability of abstract thinking.

He had a rapid downhill course, along with shakiness of trunk, rigidity of the limbs,

myoclonus, confusion, and finally, inability to speak or move on the bedside.

On electroencephalogram(EEG), continuous multifocal slow delta activities were found in all leads, especially in the right frontal areas. Brain biopsy showed, spongiosis with neuronal loss and gliosis noted at the cerebral cortex. These findings were compatible with Creutzfeldt-jacob disease.
Creutzfeldt-jacob diseaseDementiaMyoclonus
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Journal Papers > School of Medicine / Graduate School of Medicine > Neurology
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