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Differences in tumor characteristics and prognosis in newly diagnosed Ta, T1 urothelial carcinoma of bladder according to patient age.

Cho, KS; Hwang, TK; Kim, BW; Yoon, DK; Chang, SG; Kim, SJ; Park, JY; Cheon, J; Sung, GT; Hong, SJ
Urology, 73(4):828-832, 2009
Journal Title
OBJECTIVES: To evaluate the differences in tumor characteristics and prognosis according to age at presentation in patients with newly diagnosed Stage Ta, T1 urothelial carcinoma of the bladder.

METHODS: From 1998 to 2002, 1587 patients with newly diagnosed nonmuscle-invasive bladder cancer treated with transurethral resection were enrolled in this study. The median age was 63 years (range 21-98), and the median follow-up duration was 44 months (range 12-97). The study cohort was subdivided into 3 age groups: age or = 60 but or = 70 years (group 3, n = 398).

RESULTS: Comparing the clinical and pathologic characteristics, the tumor size (chi(2)(trend) = 4.01, P = .045), multiplicity (chi(2)(trend) = 14.50, P < .001), T category (chi(2)(trend) = 17.11, P < .001), and tumor grade (chi(2)(trend) = 31.36, P .05). The 5-year recurrence-free probability was 63.6%, 52.1%, and 43.9% for groups 1, 2, and 3, respectively (P < .001). The 5-year progression-free probability was 95.7%, 91.1%, and 84.2% for groups 1, 2, and 3, respectively (P < .001).

CONCLUSIONS: Stage Ta, T1 bladder urothelial carcinoma in the younger patients tended to be smaller, have fewer lesions, be less invasive, and have a more favorable tumor grade at the initial presentation. Furthermore, younger patients appeared to have a more favorable prognosis than older patients.
MeSH terms
Age FactorsAgedCarcinoma, Transitional Cell/pathology*FemaleHumansMaleMiddle AgedNeoplasm StagingPrognosisUrinary Bladder Neoplasms/pathology*
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
AJOU Authors
김, 세중
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