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Methacholine-induced Bronchial Hyperresponsiveness in Patients with Main Stem Endobronchial Tumor

Other Title
주기관지 종양 환자에서 메타콜린 기도과민성 조사
Authors
양, 두경; 이, 수걸; 손, 춘희; 노, 미숙; 최, 필조; 이, 진화; 김, 기남; 이, 기남; 이, 영목; 박, 해심; 남, 동호
Citation
Chʿŏnsik mit alrerugi, 25(2):104-109, 2005
Journal Title
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
ISSN
1226-8739
Abstract
Background: Patients with main stem endobronchial tumor may have wheeze on physical examination, which mimics bronchial asthma.



Objective: We evaluated the role of methacholine induced bronchial hyperresponsiveness, which is a hallmark of bronchial asthma, in differentiating these patients from patients with bronchial asthma.



Methods: The provocative concentrations of methacholine required to reduce FEV1 by 20% of the pre-challenge baseline (PC20) and the prevalence of hyperresponsiveness were compared among patients with main stem endobronchial tumor (n=8), patients with symptomatic bronchial asthma (n=15) and normal healthy controls (n=10).



Results: PC20 in patients with main stem endobronchial tumor (17.2+/-3.9 mg/mL) and normal healthy controls (23.9+/-3.2 mg/mL) were significantly higher than those in patients with bronchial asthma (6.3+/-2.3 mg/mL). Prevalence of hyperresponsiveness (PC20<25.0 mg/mL of methacholine) was higher in patients with bronchial asthma than that in patients with endobronchial tumor, or normal healthy controls (86.7% vs. 37.5%, 86.7% vs. 10.0%, P<.05 respectively). There were no significant correlations between clinical parameters (FVC, FEV1, peripheral blood eosinophil count, total IgE level) and PC20 in patients with main stem endobronchial tumor.



Conclusion: It is reasonable to consider the possibility of endobronchial tumor in patients who have wheeze on physical examination, but do not have methacholine-induced bronchial hyperresponsiveness.
Keywords
HyperresponsivenessAsthmaNeoplasm
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
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