A Case of Anti-Glomerular Basement Membrane Antibody Disease without Pulmonary Hemorrhage
폐출혈을 동반하지 않은 항사구체 기저막 항체질환 1예
Lim, SG; Kim, JE; Lee, JW; Lee, DH; Lim, SK; Park, IW; Cho, HK; Kim, H; Shin, GT; Lim, HE
Taehan Sinjang Hakhoe chi, 22(1):142-147, 2003
Taehan Sinjang Hakhoe chi; The Korean journal of nephrology; 대한신장학회지
Anti-glomerular basement membrane antibody mediated rapidly progressive glomerulonephritis is a rare autoimmune disease. It is characterized by acute renal failure and crescentic glomeruli with linear immune deposits along glomerular basement membrane mediated by anti-GBM antibodies. We report a case of a sixty-years-old man with generalized edema and hematuria. On admission, BUN/Creatinine was 118/19.6 ㎎/㎗, Hb was 1.02 g/㎗. On urinalysis, protein was 3+, and many RBCs were found. Renal biopsy specimen which contained 8 glomeruli showed active cellular crescent formation in all glomeruli. On immunofluorescent staining specimen, there were 4 glomeruli which showed strong IgG linear staining along the glomerular basement membrane and mild C3 &
C1q deposit along the capillry walls. The titer of anti-GBM antibody was 123 EU by ELISA (normal:<10 EU). We treated with high dose of corticosteroid and plasmapheresis, but renal function was not recovered even after 3 months of hemodialysis.
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