3 226

Cited 0 times in

The Expression of Fibroblast-derived Cytokines in Melasma

Other Title
기미에서 섬유아 세포 기원 사이토카인의 발현
Authors
김, 지연; 김, 유찬; 이, 은소; 강, 희영
Citation
Korean journal of dermatology, 43(8):1046-1052, 2005
Journal Title
Korean journal of dermatology; 대한피부과학회지
ISSN
0494-4739
Abstract
Background: The pathogenesis of melasma has not yet been clearly identified. Recently, it was reported that dermal fibroblasts played an important role in the epidermal pigmentary disorders.



Objectives: To investigate the role of fibroblast-derived cytokines, hepatocyte growth factor (HGF), stem cell factor (SCF), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1alpha in the development of melasma.



Method: Using immunohistochemistry, we measured the levels of cytokines produced by fibroblasts derived from lesional skin, compared with perilesional normal skin in 50 melasma patients.



Results: The expression of HGF and SCF was found to be significantly increased in the lesional dermis compared to perilesional normal skin. However, there was no significant difference in the expression of TNF-alpha and IL-1alpha in melasma skin.



Conclusion: These results may indicate that the dermal fibroblast-derived cytokines, HGF and SCF play an important role in the mechanism of hyperpigmentation in melasma.
Keywords
FibroblastHepatocyte growth factorMelasmaStem cell factor
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
Full Text Link
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse