The Expression of Fibroblast-derived Cytokines in Melasma
기미에서 섬유아 세포 기원 사이토카인의 발현
김, 지연; 김, 유찬; 이, 은소; 강, 희영
Korean journal of dermatology, 43(8):1046-1052, 2005
Korean journal of dermatology; 대한피부과학회지
Background: The pathogenesis of melasma has not yet been clearly identified. Recently, it was reported that dermal fibroblasts played an important role in the epidermal pigmentary disorders.
Objectives: To investigate the role of fibroblast-derived cytokines, hepatocyte growth factor (HGF), stem cell factor (SCF), tumor necrosis factor (TNF)-alpha, and interleukin (IL)-1alpha in the development of melasma.
Method: Using immunohistochemistry, we measured the levels of cytokines produced by fibroblasts derived from lesional skin, compared with perilesional normal skin in 50 melasma patients.
Results: The expression of HGF and SCF was found to be significantly increased in the lesional dermis compared to perilesional normal skin. However, there was no significant difference in the expression of TNF-alpha and IL-1alpha in melasma skin.
Conclusion: These results may indicate that the dermal fibroblast-derived cytokines, HGF and SCF play an important role in the mechanism of hyperpigmentation in melasma.
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