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Deletion of SNAP-23 results in pre-implantation embryonic lethality in mice

Authors
Suh, YH; Yoshimoto-Furusawa, A; Weih, KA; Tessarollo, L; Roche, KW; Mackem, S; Roche, PA
Citation
PloS one, 6(3):e18444-e18444, 2011
Journal Title
PloS one
ISSN
1932-6203
Abstract
SNARE-mediated membrane fusion is a pivotal event for a wide-variety of biological processes. SNAP-25, a neuron-specific SNARE protein, has been well-characterized and mouse embryos lacking Snap25 are viable. However, the phenotype of mice lacking SNAP-23, the ubiquitously expressed SNAP-25 homolog, remains unknown. To reveal the importance of SNAP-23 function in mouse development, we generated Snap23-null mice by homologous recombination. We were unable to obtain newborn SNAP-23-deficient mice, and analysis of pre-implantation embryos from Snap23(Δ/wt) matings revealed that Snap23-null blastocysts were dying prior to implantation at embryonic day E3.5. Thus these data reveal a critical role for SNAP-23 during embryogenesis.
MeSH terms
AllelesAnimalsBlastocyst/cytology/metabolismBreedingCell Death*Embryo ImplantationEmbryo Loss/*metabolism/*pathologyFemale*Gene DeletionGene TargetingHeterozygoteMiceMice, Inbred C57BLPregnancyQb-SNARE Proteins/*deficiency/metabolismQc-SNARE Proteins/*deficiency/metabolism
DOI
10.1371/journal.pone.0018444
PMID
21479242
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
AJOU Authors
서, 영호
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