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Serum angiopoietin-1 as a prognostic marker in resected early stage lung cancer.

Authors
Park, JH; Choi, H; Kim, YB; Kim, YS; Sheen, SS; Choi, JH; Lee, HL; Lee, KS; Chung, WY; Lee, S; Park, KJ; Hwang, SC; Lee, KB
Citation
Lung cancer (Amsterdam, Netherlands), 66(3):359-364, 2009
Journal Title
Lung cancer (Amsterdam, Netherlands)
ISSN
0169-50021872-8332
Abstract
PURPOSE: We evaluated the clinical significance of angiopoietins and vascular endothelial growth factor (VEGF) in patients with resected early stage lung cancer. PATIENTS AND METHODS: The study enrolled 101 patients with completely resected non-small cell lung cancer (NSCLC) of stage I or II, along with 70 healthy volunteers. Serum concentrations of angiopoietin-1, angiopoietin-2, and VEGF were measured with an ELISA. Immunohistochemical expression of angiopoietin-1 was compared with the microvessel density on the lung cancer tissues. RESULTS: The patients had lower serum angiopoietin-1 (32.1+/-9.9 ng/mL vs. 39.0+/-10.8 ng/mL, p<0.001), higher angiopoietin-2 (1949.2+/-1099.4 pg/mL vs. 1498.6+/-650.0 pg/mL, p<0.01), and higher VEGF (565.1+/-406.3 pg/mL vs. 404.6+/-254.8 pg/mL, p<0.01) levels than the controls. The angiopoietin-2 level was higher in stage II than in stage I patients (p<0.05). The levels of angiopoietin-1 (r=0.28) and angiopoietin-2 (r=0.36) each correlated with the VEGF level. Patients with a higher level of angiopoietin-1 (> or =31.2 ng/mL) had better disease-specific and relapse-free survival than those with a lower angiopoietin-1 level (<31.2 ng/mL). Angiopoietin-1 expression negatively correlated with the microvessel density. CONCLUSION: Serum angiopoietin-1 is a potential marker for predicting postoperative survival and recurrence in patients with early stage NSCLC.
MeSH terms
AgedAngiopoietin-1/biosynthesisAngiopoietin-1/blood*Angiopoietin-1/geneticsAngiopoietin-2/bloodCarcinoma, Non-Small-Cell Lung/blood*Carcinoma, Non-Small-Cell Lung/diagnosis*Carcinoma, Non-Small-Cell Lung/pathologyCarcinoma, Non-Small-Cell Lung/physiopathologyDisease-Free SurvivalEnzyme-Linked Immunosorbent AssayFemaleHumansImmunohistochemistryLung/metabolism*Lung/pathologyLung Neoplasms/blood*Lung Neoplasms/diagnosis*Lung Neoplasms/pathologyLung Neoplasms/physiopathologyMaleMicrovessels/pathologyMiddle AgedNeoplasm Recurrence, LocalNeoplasm StagingPrognosisTumor Markers, Biological/blood*Vascular Endothelial Growth Factor A/blood
DOI
10.1016/j.lungcan.2009.03.002
PMID
19339077
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
Journal Papers > School of Medicine / Graduate School of Medicine > Thoracic & Cardiovascular Surgery
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
AJOU Authors
박주헌최호김영배신승수최진혁이규성정우영이성수박경주황성철이기범박광주
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