197 264

Cited 6 times in

Role of corticotrophin-releasing factor in the stress-induced dilation of esophageal intercellular spaces

Authors
Cho, YJ; Kim, JH; Yim, HE; Lee, da M; Im, SK; Lee, KJ
Citation
Journal of Korean medical science, 26(2):279-283, 2011
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
Corticotrophin-releasing factor (CRF) plays a major role in coordinating stress responses. We aimed to test whether blocking endogenous CRF activity can prevent the stress-induced dilation of intercellular spaces in esophageal mucosa. Eighteen adult male rats were divided into 3 groups: 1) a non-stressed group (the non-stressed group), 2) a saline-pretreated stressed group (the stressed group), 3) and an astressin-pretreated stressed group (the astressin group). Immediately after completing the experiments according to the protocol, distal esophageal segments were obtained. Intercellular space diameters of esophageal mucosa were measured by transmission electron microscopy. Blood was sampled for the measurement of plasma cortisol levels. Mucosal intercellular spaces were significantly greater in the stressed group than in the non-stressed group. Mucosal intercellular spaces of the astressin group were significantly smaller than those of the stressed group. Plasma cortisol levels in the stressed group were significantly higher than in the non-stressed group. Pretreatment with astressin tended to decrease plasma cortisol levels. Acute stress in rats enlarges esophageal intercellular spaces, and this stress-induced alteration appears to be mediated by CRF. Our results suggest that CRF may play a role in the pathophysiology of reflux-induced symptoms or mucosal damage.
MeSH terms
AnimalsCorticotropin-Releasing Hormone/*antagonists & inhibitors/metabolism/pharmacologyEsophagus/anatomy & histology/*drug effectsExtracellular Space/*drug effectsHydrocortisone/bloodMaleMucous Membrane/anatomy & histology/*drug effectsNeuroprotective Agents/pharmacologyPeptide Fragments/*pharmacologyRatsRats, Wistar*Stress, Psychological/blood/physiopathology
DOI
10.3346/jkms.2011.26.2.279
PMID
21286022
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
김, 장희임, 현이이, 다미임, 선교이, 광재
Full Text Link
Files in This Item:
279-283.pdfDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse