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The C609T variant of NQO1 is associated with carotid artery plaques in patients with type 2 diabetes.

Authors
Han, SJ; Kang, ES; Kim, HJ; Kim, SH; Chun, SW; Ahn, CW; Cha, BS; Nam, M; Lee, HC
Citation
Molecular genetics and metabolism, 97(1):85-90, 2009
Journal Title
Molecular genetics and metabolism
ISSN
1096-71921096-7206
Abstract
OBJECTIVE: Atherosclerosis in patients with type 2 diabetes has been linked to oxidative stress. NADP[1]:quinone oxidoreductase 1 (NQO1) plays a key role in cellular antioxidant defense. Recent reports suggest that highly expressed and inducible endogenous NQO1 from cardiovascular cells may act as a potential superoxide scavenger. We examined the relationship between the risk of NQO1 C609T polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes. METHODS: We recruited 601 (Seoul set) and 233 (Koyang set) unrelated patients with type 2 diabetes from independent groups. The C609T variant of NQO1 was genotyped by Taqman RT-PCR. Mean and maximum carotid intima-media thickness (IMT) and carotid artery plaques were measured by high-resolution ultrasonography. RESULTS: Patients with the T allele exhibited a higher prevalence of atherosclerotic plaques than non-T allele carriers in both sets (Seoul set vs. Koyang set, p=0.021, p=0.023, respectively). After adjusting for age, sex, duration of diabetes, systolic blood pressure, body mass index, current smoking, HDL-cholesterol, LDL-cholesterol and HbA1c, subjects with the T allele had a significantly higher risk of carotid artery plaques (Seoul set vs. Koyang set, OR=1.65, p=0.015; OR=2.00, p=0.037, respectively) than subjects with the CC genotype. CONCLUSION: These results suggest that the C609T polymorphism of NQO1 is associated with carotid artery plaques in type 2 diabetic patients.
MeSH terms
Carotid Artery, Common/pathologyCarotid Stenosis/complications*Carotid Stenosis/enzymology*Carotid Stenosis/geneticsDiabetes Mellitus, Type 2/complications*Diabetes Mellitus, Type 2/enzymology*Diabetes Mellitus, Type 2/geneticsFemaleGene FrequencyGenetic Predisposition to Disease*HumansMaleMiddle AgedNAD(P)H Dehydrogenase (Quinone)/genetics*Polymorphism, Single Nucleotide/genetics*Tunica Intima/pathologyTunica Media/pathology
DOI
10.1016/j.ymgme.2009.01.012
PMID
19251446
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
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