1 241

Cited 52 times in

Comparison of everolimus- and sirolimus-eluting stents in patients with long coronary artery lesions: a randomized LONG-DES-III (Percutaneous Treatment of LONG Native Coronary Lesions With Drug-Eluting Stent-III) Trial.

Park, DW; Kim, YH; Song, HG; Ahn, JM; Kim, WJ; Lee, JY; Kang, SJ; Lee, SW; Lee, CW; Park, SW; Yun, SC; Seung, KB; Yang, TH; Lee, SG; Lee, JH; Seong, IW; Cheong, SS; Lee, BK; Lee, NH; Lee, K; Kim, HS; Jeon, DS; Kim, MK; Nah, DY; Tahk, SJ; Park, SJ
JACC. Cardiovascular interventions, 4(10):1096-1103, 2011
Journal Title
JACC. Cardiovascular interventions
OBJECTIVES: This study compared everolimus-eluting stents (EES) and sirolimus-eluting stents (SES) for long coronary lesions.

BACKGROUND: Outcomes remain relatively unfavorable for stent-based coronary intervention of lesions with long diseased segments.

METHODS: This randomized, multicenter, prospective trial compared the use of long EES with SES in 450 patients with long (≥ 25 mm) native coronary lesions. The primary endpoint of the trial was in-segment late luminal loss at 9-month angiographic follow-up.

RESULTS: The EES and SES groups had similar baseline characteristics. Lesion length was 34.0 ± 15.4 mm in the EES group and 34.3 ± 13.5 mm in the SES group (p = 0.85). Nine-month angiographic follow-up was performed in 80% of the EES group and 81% of the SES group (p = 0.69). In-segment late loss as the primary study endpoint was significantly larger in the EES group than in the SES group (0.17 ± 0.41 mm vs. 0.09 ± 0.30 mm, p for noninferiority = 0.96, p for superiority = 0.04). The in-segment binary restenosis rate was also higher in the EES group than in the SES group (7.3% vs. 2.7%, p = 0.046). However, in-stent late loss (0.22 ± 0.43 mm vs. 0.18 ± 0.28 mm, p = 0.29) and in-stent binary restenosis rate (3.9% vs. 2.7%, p = 0.53) were similar among the 2 groups. The incidence of any clinical outcomes (death, myocardial infarction, stent thrombosis, target lesion revascularization, and composite outcomes) was not statistically different between the 2 groups.

CONCLUSIONS: For patients with long native coronary artery disease, EES implantation was associated with greater angiographic in-segment late loss and higher rates of in-segment restenosis compared with SES implantation. However, clinical outcomes were both excellent and not statistically different.
MeSH terms
Angioplasty, Balloon, CoronaryCoronary AngiographyCoronary Restenosis/*drug therapy/mortality/therapyCoronary Vessels/*pathology*Drug-Eluting StentsFemaleHumansImmunosuppressive Agents/*therapeutic useKaplan-Meier EstimateMaleMiddle AgedRecurrenceSirolimus/*analogs & derivatives/*therapeutic useStatistics as TopicTime Factors
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Cardiology
AJOU Authors
탁, 승제
Full Text Link
RIS (EndNote)
XLS (Excel)


해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.