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Intake of brown rice lees reduces waist circumference and improves metabolic parameters in type 2 diabetes.

Authors
Kim, TH; Kim, EK; Lee, MS; Lee, HK; Hwang, WS; Choe, SJ; Kim, TY; Han, SJ; Kim, HJ; Kim, DJ; Lee, KW
Citation
Nutrition research (New York, N.Y.), 31(2):131-138, 2011
Journal Title
Nutrition research (New York, N.Y.)
ISSN
0271-53171879-0739
Abstract
Intake of whole grains has been associated with lower risks of type 2 diabetes and cardiovascular disease. Brown rice is unrefined whole grain and is produced by removing the outermost layers containing the germ and bran, which are rich in nutrients including dietary fiber, vitamins, minerals, and other unmeasured dietary constituents. The lees of brown rice (LB) are by-products of its fermentation in the process of manufacturing takju, a Korean turbid rice wine. In this study, we hypothesized that intake of LB would reduce waist circumference, a strong risk factor for cardiovascular disease in type 2 diabetic patients. A randomized, double-blind, placebo-controlled study was scheduled for 12 weeks. Thirty subjects were randomly assigned to receive a supplement prepared from the LB or from a mixed-grain dietary product (MG). Body weight, waist circumference, body composition, lipid profiles, and other laboratory parameters were measured. The LB group showed greater reduction in waist circumference (LB: 87.9 ± 8.8 to 85.1 ± 9.0 cm; MG: 86.9 ± 8.8 to 86.0 ± 9.3 cm; P = .032). In addition, the consumption of LB resulted in a significantly greater decrease in the level of aspartate transaminase (LB: 25.4 ± 8.5 to 21.0 ± 5.1 IU/mL; MG: 22.5 ± 5.3 to 22.4 ± 5.7 IU/mL; P = .044) and alanine transaminase (LB: 28.6 ± 11.3 to 21.9 ± 8.2 IU/mL; MG: 24.4 ± 7.5 to 24.5 ± 9.9 IU/mL; P = .038). Consumption of the LB was associated with a decreased waist circumference in type 2 diabetic patients. Further study is required to evaluate the metabolic effect of the extract of the LB in type 2 diabetes.
MeSH terms
AdultBlood Glucose/analysisBody CompositionBody WeightCardiovascular Diseases/complicationsCholesterol/bloodCholesterol, HDL/bloodCholesterol, LDL/bloodDiabetes Mellitus, Type 2/drug therapy/*metabolismDietary Fiber/*administration & dosageDietary SupplementsDouble-Blind MethodFemaleGlucose Tolerance TestHumansMaleMiddle AgedOryza sativa/*chemistryRisk Factors*Waist CircumferenceWeight Loss
DOI
10.1016/j.nutres.2011.01.010
PMID
21419317
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
이, 민석한, 승진김, 혜진김, 대중이, 관우
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