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Apolipoprotein B/A1 ratio is associated with free androgen index and visceral adiposity and may be an indicator of metabolic syndrome in male children and adolescents.

Authors
Lee, YH; Choi, SH; Lee, KW; Kim, DJ
Citation
Clinical endocrinology, 74(5):579-586, 2011
Journal Title
Clinical endocrinology
ISSN
0300-06641365-2265
Abstract
OBJECTIVE: A high apolipoprotein B/apolipoprotein A1 (apoB/A1) ratio is strongly associated with cardiometabolic diseases. However, few studies have examined this ratio in children and adolescents. The aim of our study was to determine significant factors related to the apoB/A1 ratio and examine its association with paediatric metabolic syndrome.



PATIENTS AND METHODS: Sixty-seven male children and adolescents were recruited. We measured anthropometric parameters, fat areas by abdominal computed tomography, fasting glucose, insulin, lipid profiles, apoB, apoA1, adiponectin, free androgen index (FAI) and oestradiol.



RESULTS: Thirty per cent of participants (n = 20) were identified as having paediatric metabolic syndrome. The apoB/A1 ratio was significantly correlated with BMI z-score, waist circumference, waist-to-hip ratio (WHR), waist-to-height ratio, abdominal fat areas, total cholesterol, triglycerides, LDL-cholesterol, HDL-cholesterol, adiponectin and leptin. In addition to lipid profiles, WHR was identified as a significant independent variable correlated with the apoB/A1 ratio. Obese boys with a high FAI (>75th percentile) had significantly lower adiponectin and higher apoB/A1 ratios than those with a low FAI. The apoB/A1 ratio was higher in subjects with high visceral fat (>50th percentile) and a high FAI when compared with subjects with low visceral fat and a low FAI. The prevalence of paediatric metabolic syndrome was significantly associated with increasing tertiles of the apoB/A1 ratio (highest tertile; odds ratio = 18·8 [95% confidence interval = 1·8-198·8], P < 0·05).



CONCLUSION: ApoB/A1 ratio was significantly higher in viscerally obese male children and adolescents with high levels of FAI and was associated with increased frequency of paediatric metabolic syndrome.
MeSH terms
AdolescentAndrogens/*bloodAnthropometryApolipoprotein A-I/*bloodApolipoproteins B/*bloodBiological MarkersBody CompositionChildHumansIntra-Abdominal FatMaleMetabolic Syndrome X/blood/*diagnosis
DOI
10.1111/j.1365-2265.2010.03953.x
PMID
21138461
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
이, 관우김, 대중
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