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Trough plasma imatinib levels are correlated with optimal cytogenetic responses at 6 months after treatment with standard dose of imatinib in newly diagnosed chronic myeloid leukemia.

Sohn, SK; Oh, SJ; Kim, BS; Ryoo, HM; Chung, JS; Joo, YD; Bang, SM; Jung, CW; Kim, DH; Yoon, SS; Kim, H; Lee, HG; Won, JH; Min, YH; Cheong, JW; Park, JS; Eom, KS; Hyun, MS; Kim, MK; Park, MR; Park, J; Kim, CS; Kim, HJ; Kim, YK; Park, EK; Zang, DY; Jo, DY; Moon, JH; Park, SY
Leukemia & lymphoma, 52(6):1024-1029, 2011
Journal Title
Leukemia & lymphoma
To investigate the correlation of trough imatinib mesylate (IM) levels with cytogenetic or molecular responses, we measured trough IM levels in patients with chronic myeloid leukemia, chronic phase (CML-CP), at 6 months of treatment with a standard dose of IM. Eighty-seven newly diagnosed patients with CML-CP were prospectively enrolled. Seventy-eight patients (89.7%) showed an optimal response (complete or partial cytogenetic response) at 6 months. Trough IM levels were 1378 ± 725 ng/mL. When categorized into two groups, there was a statistically significant difference in numbers of patients with optimal and suboptimal responses at 6 months (group with  <1000: 80.6% vs. 19.4%;  ≥ 1000: 94.6% vs. 5.4%; p = 0.032), and in numbers of patients with early major molecular response (early-MMR) and without MMR at 6 months (group with  <1000: 3.2% vs. 96.8%;  ≥ 1000: 21.4% vs. 78.6%; p = 0.047). In conclusion, the incidence of optimal cytogenetic response or early-MMR in patients with CML-CP treated with IM for 6 months was significantly higher in those with a trough level of  ≥ 1000 compared with those with a level of <1000. Dose escalation of IM can be one option in patients with CML showing suboptimal response or resistance to the standard dose of IM, especially with low trough plasma IM levels (<1000 ng/mL).
MeSH terms
AdolescentAdultAgedAntineoplastic Agents/adverse effects/pharmacokinetics/therapeutic useFemaleFusion Proteins, bcr-abl/geneticsHumansLeukemia, Myeloid, Chronic-Phase/*drug therapy/*geneticsLogistic ModelsMaleNeutropenia/chemically inducedPiperazines/blood/pharmacokinetics/*therapeutic useProspective StudiesPyrimidines/blood/pharmacokinetics/*therapeutic useReverse Transcriptase Polymerase Chain ReactionThrombocytopenia/chemically inducedTime FactorsTranscription, Genetic/drug effectsTreatment OutcomeYoung Adult
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Journal Papers > School of Medicine / Graduate School of Medicine > Hematology-Oncology
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박, 준성
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