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Association between variable number tandem repeats within the 3' flanking region of the interleukin-6 gene and systemic lupus erythematosus in Korean patients.

Authors
Jeon, JY; Kim, HA; Kim, SH; Suh, CH
Citation
Lupus, 20(11):1161-1165, 2011
Journal Title
Lupus
ISSN
0961-20331477-0962
Abstract
Variable number tandem repeat (VNTR) polymorphism located in the 3' flanking region of the interleukin-6 (IL-6) gene was examined in Koreans with systemic lupus erythematosus (SLE). We identified 15 VNTR alleles (K1 to K15) in the 3' flanking region by Genescan analysis. The VNTR K8 allele, a 648-base pair (bp) allele, was most commonly found in Koreans, being present in 74.8% of the SLE patients and 70.3% of the normal controls. The VNTR K9 (642 bp) allele was associated with susceptibility to SLE. In addition, the VNTR K9 was significantly associated with leukopenia (p = 0.048), thrombocytopenia (p = 0.020), and elevated C-reactive protein (p = 0.019). These data suggest that the VNTR K9 in the 3' flanking region of the IL-6 gene may be associated with disease susceptibility and the clinical phenotypes of SLE.
MeSH terms
3' Flanking RegionAdultAllelesAsian Continental Ancestry Group/geneticsBase SequenceCase-Control StudiesDNA Primers/geneticsFemaleGenetic Association StudiesHumansInterleukin-6/*geneticsLupus Erythematosus, Systemic/*genetics/*immunologyMaleMiddle Aged*Minisatellite RepeatsRepublic of KoreaYoung Adult
DOI
10.1177/0961203311405704
PMID
21700657
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Rheumatology
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
김, 현아김, 승현서, 창희
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