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Non-catch-up growth in intrauterine growth-retarded rats showed glucose intolerance and increased expression of PDX-1 mRNA.

Authors
Lim, JS; Lee, JA; Hwang, JS; Shin, CH; Yang, SW
Citation
Pediatrics international : official journal of the Japan Pediatric Society, 53(2):181-186, 2011
Journal Title
Pediatrics international : official journal of the Japan Pediatric Society
ISSN
1328-80671442-200X
Abstract
BACKGROUND:   Children born with intrauterine growth retardation (IUGR) show long-term complications like non-catch-up growth and type 2 diabetes. We hypothesize that the duration of malnutrition influences the growth and pancreatic development in IUGR. The pancreatic duodenal homeobox-1 (PDX-1) expression might also be different because it links glucose metabolism to the regulation of insulin gene transcription in the pancreas.



METHODS:   We made an IUGR rat model with a low-protein diet (8% casein) during gestational periods. Catch-up rats (CU) were given normal lab chow immediately after birth. Non-catch-up rats (NCU) were given normal lab chow after lactation periods. PDX-1 mRNA level, islet areas and intravenous glucose tolerance test (IVGTT) were assessed in each group and compared with control rats (C) at the 16th week.



RESULTS:   The weight and length of CU and C rats were not different after 3 weeks, while NCU rats were smaller than C and CU rats (P < 0.05). In IVGTT, the 20-min and 50-min glucose level and area under the curve for glucose were increased in NCU rats compared with those values in C and CU rats (P < 0.05). The islet area of NCU rats was smaller than that of C and CU rats (P < 0.05). In contrast, PDX-1 mRNA levels of NCU rats were higher than those of C rats (P < 0.05). CU rats showed normal glucose response in IVGTT with increased islet number and size.



CONCLUSIONS:   IUGR rats that failed to undergo catch-up growth might be prone to abnormal glucose tolerance, decreased islet size, and increased PDX-1 mRNA levels in early adult life.
MeSH terms
AnimalsBody WeightDiabetes Mellitus, Type 2/etiology/physiopathologyDiet, Protein-RestrictedDisease Models, AnimalFemaleFetal Growth Retardation/epidemiology/*metabolism/physiopathologyGlucose Intolerance/complicationsGlucose Tolerance TestGrowthHomeodomain Proteins/*metabolismInsulin Resistance/physiologyIslets of Langerhans Transplantation/pathologyLactationMaleMalnutrition/therapyRNA, Messenger/metabolismRatsRats, WistarTrans-Activators/*metabolism
DOI
10.1111/j.1442-200X.2010.03204.x
PMID
20626638
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pediatrics & Adolescent Medicine
AJOU Authors
황, 진순
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