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A multicenter study on extramammary Paget's disease in Korea.

Authors
Lee, SJ; Choe, YS; Jung, HD; Ahn, SK; Cha, YC; Cho, KH; Choi, HY; Chung, KY; Huh, CH; Kim, IH; Kim, KH; Kim, MB; Kim, MH; Kim, YC; Lee, JB; Lee, MW; Lee, MG; Lee, WJ; Shin, DH; Shin, JH; Suh, KS; Won, YH; Korean Society for Skin Cancer and Korean Dermatopathology Research Group
Citation
International journal of dermatology, 50(5):508-515, 2011
Journal Title
International journal of dermatology
ISSN
0011-90591365-4632
Abstract
BACKGROUND: There has been little research on extramammary Paget's disease (EMPD) conducted in Asia.



METHODS: The aim of this multicenter study was to investigate the clinicopathological features, biological behavior, and treatment of EMPD in 194 Korean patients over a five-year period.



RESULTS: As expected, this disease exhibited a male dominance (3.9:1) pattern. To distinguish the true association of malignancy with EMPD from coincidental occurrence of malignancy, we modified Chanda's guidelines. This analysis determined that there was an accompanying malignancy in 26 patients (14.4%), which included stomach (six cases), rectum (three cases), and colon (three cases) malignancies. With regard to treatment, 112 patients (58%) underwent conventional excisions, and 22 (11.4%) had Mohs surgery. Follow-up data for periods of 3-180 months were available for 147 patients; these data indicated that 42 patients (28.6%) experienced local recurrences. Patients who underwent Mohs micrographic surgery experienced a lower rate of recurrence (12.5%) than patients who underwent conventional excision (33.3%).



CONCLUSIONS: In summary, this Korean population-based study demonstrated that the clinical features of EMPD, such as gender predominance, are consistent with reports from other Asian population-based studies. However, this study additionally demonstrated that the rate of association with malignancy in the Korean population (14.4%) was higher than that observed in other Asian studies.
MeSH terms
AdultAgedAged, 80 and over*Colonic Neoplasms/diagnosis/epidemiology/pathology/surgeryFemaleHumansMaleMiddle AgedMohs Surgery/methodsMulticenter Studies as TopicNeoplasm Recurrence, Local/surgery*Paget Disease, Extramammary/diagnosis/epidemiology/pathology/surgery*Rectal Neoplasms/diagnosis/epidemiology/pathology/surgeryRepublic of Korea/epidemiologyRetrospective StudiesSex Factors*Stomach Neoplasms/diagnosis/epidemiology/pathology/surgeryTreatment OutcomeYoung Adult
DOI
10.1111/j.1365-4632.2010.04661.x
PMID
21506963
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
김, 유찬
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