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Skin rejuvenating effects of chemical peeling: a study in photoaged hairless mice.

Authors
Han, SH; Kim, HJ; Kim, SY; Kim, YC; Choi, GS; Shin, JH
Citation
International journal of dermatology, 50(9):1075-1082, 2011
Journal Title
International journal of dermatology
ISSN
0011-90591365-4632
Abstract
Background  Chemical peeling is a dermatologic treatment for skin aging. However, the mechanism by which the chemical peel achieves its results is not clear. We investigated the effects of chemical peeling and the mechanism of wrinkle reduction in photoaged hairless mice skin. Methods  After inducing photoaged skin in hairless mice by repetitive ultraviolet-B irradiation applied over 14 weeks, we applied trichloroacetic acid (TCA) 30%, TCA 50%, and phenol on areas of the same size on the backs of the mice. Punch biopsies were obtained 7, 14, 28, and 60 days after the procedure for histologic and immunohistochemical analyses. Results  Histologic examination showed an increase in dermal thickness, collagen fibers, and elastic fibers in the dermis of intervention groups compared with control groups. These increases were maintained significantly for 60 days. Conclusions  This study demonstrates that chemical peeling reduces wrinkles and regenerates skin by increasing dermal thickness and the amount of collagen and elastic fibers in photoaged skin.
MeSH terms
Animals*ChemexfoliationCollagen/metabolismElastic Tissue/pathologyMiceMice, HairlessPhenol/administration & dosage*RejuvenationSkin/metabolism/pathology*Skin AgingTrichloroacetic Acid/administration & dosage
DOI
10.1111/j.1365-4632.2010.04712.x
PMID
22126868
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
AJOU Authors
김, 유찬
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