159 524

Cited 15 times in

Lymph-vascular space invasion as a significant risk factor for isolated para-aortic lymph node metastasis in endometrial cancer: a study of 203 consecutive patients.

DC Field Value Language
dc.contributor.authorChang, SJ-
dc.contributor.authorKong, TW-
dc.contributor.authorKim, WY-
dc.contributor.authorYoo, SC-
dc.contributor.authorYoon, JH-
dc.contributor.authorChang, KH-
dc.contributor.authorRyu, HS-
dc.date.accessioned2012-05-08T02:35:43Z-
dc.date.available2012-05-08T02:35:43Z-
dc.date.issued2011-
dc.identifier.issn1068-9265-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/6843-
dc.description.abstractBACKGROUND: The purpose of this study was to investigate various pathologic risk factors associated with para-aortic lymph node metastasis (LNM) in surgically staged patients with endometrial cancer.



MATERIALS AND METHODS: We performed a retrospective analysis of 203 consecutive patients with endometrial cancer who were surgically staged from 2000 to 2009. The association among the various pathologic variables for para-aortic LNM was determined with univariate and multivariate analyses.



RESULTS: Of 203 patients, 29 patients (14.3%) had LNM. Also, 10 patients (4.9%) had only pelvic LNM, 14 (6.9%) had both pelvic and para-aortic LNM, and 5 (2.5%) had para-aortic LNM without pelvic LN involvements. Histologic type (P = .001), tumor grade (P < .001), tumor size (P = .003), depth of myometrial invasion (P < .001), cervical invasion (P < .001), parametrial invasion (P = .002), lymph-vascular space invasion (LVSI) (P < .001), serosal/adnexal invasion (P < .001), positive cytology (P = .002), peritoneal seeding (P < .001), and pelvic LNM (P < .001) were significant pathologic factors for para-aortic LNM. On multivariate analysis, cervical invasion (P = .032), LVSI (P = .018), and positive pelvic LNs (P = .002) were independent factors for para-aortic LNM. With regard to isolated para-aortic LNM, tumor grade (P = .017) and LVSI (P = .002) were significant factors for LN involvements. On multivariate analysis, LVSI (P = .004) was the only significant independent factor.



CONCLUSIONS: LVSI correlates significantly with the risk of isolated para-aortic LNM in endometrial cancer patients.
-
dc.language.isoen-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCarcinoma, Papillary/*secondary/surgery-
dc.subject.MESHCarcinosarcoma/*secondary/surgery-
dc.subject.MESHCystadenocarcinoma, Serous/*secondary/surgery-
dc.subject.MESHEndometrial Neoplasms/*pathology/surgery-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHLymph Nodes/*pathology/surgery-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHLymphatic Vessels/*pathology/surgery-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Invasiveness-
dc.subject.MESHPeritoneal Neoplasms/*secondary/surgery-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSurvival Rate-
dc.subject.MESHTreatment Outcome-
dc.titleLymph-vascular space invasion as a significant risk factor for isolated para-aortic lymph node metastasis in endometrial cancer: a study of 203 consecutive patients.-
dc.typeArticle-
dc.identifier.pmid20607418-
dc.contributor.affiliatedAuthor장, 석준-
dc.contributor.affiliatedAuthor김, 우영-
dc.contributor.affiliatedAuthor유, 승철-
dc.contributor.affiliatedAuthor윤, 종혁-
dc.contributor.affiliatedAuthor장, 기홍-
dc.contributor.affiliatedAuthor유, 희석-
dc.type.localJournal Papers-
dc.identifier.doi10.1245/s10434-010-1206-x-
dc.citation.titleAnnals of surgical oncology-
dc.citation.volume18-
dc.citation.number1-
dc.citation.date2011-
dc.citation.startPage58-
dc.citation.endPage64-
dc.identifier.bibliographicCitationAnnals of surgical oncology, 18(1):58-64, 2011-
dc.identifier.eissn1534-4681-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Files in This Item:
20607418.pdfDownload

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse