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Treatment patterns and outcomes in bulky stage IB2 cervical cancer patients: a single institution's experience over 14 years.

Authors
Kim, WY; Chang, SJ; Chang, KH; Yoo, SC; Chun, M; Ryu, HS
Citation
Gynecologic and obstetric investigation, 71(1):19-23, 2011
Journal Title
Gynecologic and obstetric investigation
ISSN
0378-73461423-002X
Abstract
AIM: The aim of this study was to assess various treatment options in stage IB2 cervical cancer patients.



METHODS: Between January 1995 and May 2007, 63 patients with stage IB2 were treated by radical hysterectomy (n = 28), primary concurrent chemoradiation (CCRT, n = 16) or radiation therapy (RT, n = 19). Disease-free survival (DFS) and overall survival (OS) were compared between these treatment modalities.



RESULTS: The 3-year DFS of the surgical approach group was 67.5% compared to 70.3% of the primary RT/CCRT group (p = 0.603). The 5-year OS of all patients was 75.9%. The 5-year OS of the surgical approach group was 81.6% compared to 76.2% of the primary RT/CCRT group (p = 0.578). Twelve (42.8%) of 28 surgically treated patients had high-risk pathologic factors. Out of 20 premenopausal patients who underwent the surgical approach, ovarian preservation was possible in 13 patients without adjuvant CCRT. Of these 13 patients, 7 patients did not experience disease recurrence and continued normal ovarian function.



CONCLUSION: Both radical hysterectomy and primary RT/CCRT are effective treatment options in IB2 cervical cancer. In addition, the surgical approach can be considered for preserving ovarian function in premenopausal IB2 cervical cancer patients.
MeSH terms
*Adenocarcinoma/drug therapy/radiotherapy/surgeryAdultAgedAntineoplastic Agents/therapeutic use*Carcinoma, Squamous Cell/drug therapy/radiotherapy/surgeryCombined Modality TherapyDisease-Free SurvivalFemaleHumans*HysterectomyMiddle AgedNeoplasm Recurrence, LocalOvary/physiologyRadiotherapyRetrospective StudiesTreatment Outcome*Uterine Cervical Neoplasms/drug therapy/radiotherapy/surgeryYoung Adult
DOI
10.1159/000320722
PMID
21160190
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
AJOU Authors
김, 우영장, 석준장, 기홍유, 승철전, 미선유, 희석
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