117 258

Cited 19 times in

Blood lead levels and increased bronchial responsiveness.

Authors
Min, JY; Min, KB; Kim, R; Cho, SI; Paek, D
Citation
Biological trace element research, 123(1-3):41-46, 2008
Journal Title
Biological trace element research
ISSN
0163-49841559-0720
Abstract
The immune system is one of the targets most sensitive to lead toxicity, and the association between lead exposure and serum immunoglobulin E (IgE) has been published. Recent studies also reported that lead caused the development of IgE-mediated allergy. To investigate whether blood lead levels contribute to other allergic conditions, we examined the effect of blood lead on bronchial responsiveness (BR) in the general population. We performed a cross-sectional study with adults aged 19 to 58 years in a Korean community. Blood lead level and the methacholine provocation test were performed. The overall mean blood lead level was 2.9 microg/dl, and the mean BR index was 1.14. The percent of subjects with clinically diagnosed asthma was 21 (4%) and there was no difference in blood lead level with and without asthma. In the multiple regression model, the elevation of blood lead level was related to the increase of BR after adjusting for age, sex, height, smoking status, and the presence of asthma. Blood lead level was significantly associated with increased BR that came from the elevation of the IgE level with lead exposure. Lead may contribute to the increase of asthma and other allergic conditions.
MeSH terms
AdultAsthma/bloodAsthma/diagnosisAsthma/physiopathologyBronchial Hyperreactivity/blood*Bronchial Hyperreactivity/physiopathologyCross-Sectional StudiesFemaleHumansKoreaLead/blood*MaleMethacholine Chloride/administration & dosageMiddle Aged
DOI
10.1007/s12011-008-8099-6
PMID
18286239
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Occupational & Environmental Medicine
AJOU Authors
민경복
Files in This Item:
Full-Text Not Available.txtDownload
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse