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Tissue transglutaminase can be involved in airway inflammation of toluene diisocyanate-induced occupational asthma.

Authors
Hur, GY; Kim, SH; Park, SM; Ye, YM; Kim, CW; Jang, AS; Park, CS; Hong, CS; Park, HS
Citation
Journal of clinical immunology, 29(6):786-794, 2009
Journal Title
Journal of clinical immunology
ISSN
0271-91421573-2592
Abstract
BACKGROUND: This study was conducted to evaluate whether tissue transglutaminase (tTG) may be involved in airway inflammation of toluene diisocyanate-induced occupational asthma (TDI-OA).



METHODS: We enrolled 93 patients with TDI-OA, 177 asymptomatic exposed subjects, 43 patients with allergic asthma, and 70 unexposed normal controls. The prevalence of serum immunoglobulin G (IgG) to tTG in the TDI-OA group (20.2%) was significantly higher than that in the three other groups (P < 0.001).



RESULTS: TDI-OA patients with serum IgG to tTG had significantly lower methacholine PC(20) values (P < 0.02) and significantly higher prevalence of specific immunoglobulin E to vapor type TDI-human serum albumin conjugate (P < 0.01; r(2) = 0.411, P < 0.05). TDI exposure could increase tTG activity via reactive oxygen species (ROS) production, which was found to cross-link with cytokeratin 19 on immunoblot analysis.



CONCLUSION: Therefore, TDI exposure may activate tTG via ROS-mediated mechanism in the airway epithelium leading to persistent airway inflammation in TDI-OA patients.
MeSH terms
AdultAsthma/chemically induced*Asthma/pathologyCase-Control StudiesFemaleHumansImmunoglobulin E/bloodImmunoglobulin G/bloodInflammation/chemically induced*MaleMiddle AgedOccupational Diseases/chemically induced*Reactive Oxygen SpeciesRespiratory Hypersensitivity/pathology*Toluene 2,4-Diisocyanate/toxicity*Transglutaminases/immunologyTransglutaminases/physiology*Young Adult
DOI
10.1007/s10875-009-9314-8
PMID
19562471
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Pharmacology
AJOU Authors
박, 상면예, 영민박, 해심
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