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Serum fibroblast growth factor 21 was elevated in subjects with type 2 diabetes mellitus and was associated with the presence of carotid artery plaques

Authors
An, SY; Lee, MS; Yi, SA; Ha, ES; Han, SJ; Kim, HJ; Kim, DJ; Lee, KW
Citation
Diabetes research and clinical practice, 96(2):196-203, 2012
Journal Title
Diabetes research and clinical practice
ISSN
0168-82271872-8227
Abstract
AIMS: Fibroblast growth factor 21 (FGF21) is an important regulator of glucose/lipid metabolism. Although there are studies examining the relationship between serum FGF21 levels and glucose homeostasis, the role of FGF21 remains unclear. The objective of this study was to examine whether serum FGF21 levels are associated with metabolic parameters in subjects with varying degrees of obesity and glucose tolerance and with complications in subjects with type2 diabetes mellitus (T2DM).



METHODS: The study consisted of 213 subjects who were lean and had normal glucose tolerance (lean NGT), were overweight with NGT, had impaired glucose tolerance (IGT) or had T2DM. Serum FGF21 levels and their associations with the parameters of adiposity, glucose tolerance and the presence of diabetic complications were examined.



RESULTS: The serum FGF21 levels in T2DM were higher than in lean NGT. Serum FGF21 levels showed a positive correlation with the urine albumin-to-creatinine ratio (ACR) in all subjects except for the T2DM subjects, who showed a correlation after adjustment of age, gender and body mass index. Moreover, the subjects with carotid artery plaque showed higher serum FGF21 levels than those without complications.



CONCLUSION: Serum FGF21 levels were associated with the urine ACR and diabetic complications including carotid artery plaque.
MeSH terms
AdultCarotid Stenosis/*bloodDiabetes Mellitus, Type 2/*blood/complicationsFemaleFibroblast Growth Factors/*bloodHumansMale
DOI
10.1016/j.diabres.2012.01.004
PMID
22293928
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Endocrinology & Metabolism
AJOU Authors
안, 소연이, 민석한, 승진김, 혜진김, 대중이, 관우
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