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Association of three sets of high-affinity IgE receptor (FcepsilonR1) polymorphisms with aspirin-intolerant asthma.

Palikhe, NS; Kim, SH; Cho, BY; Ye, YM; Hur, GY; Park, HS
Respiratory medicine, 102(8):1132-1139, 2008
Journal Title
Respiratory medicine
BACKGROUND AND OBJECTIVE: The high-affinity IgE receptor comprises a tetramer of the ligand-binding alpha chain, a signal-augmenting beta chain, and a signal-transducing gamma chain dimer on mast cells. We hypothesized that the three subsets of the FCER1 gene may play a role in the development of the aspirin-intolerant asthma (AIA) phenotype and analyzed these genetic polymorphisms in association with clinical parameters in AIA patients.

SUBJECTS AND METHODS: Six polymorphisms of FCER1 (FCERIA-344C>T, FCER1A-95T>C, MS4A2-109T>C, MS4A2 E237G, FCER1G-237A>G, FCER1G-54G>T) were genotyped in 126 AIA patients compared to 177 patients with aspirin-tolerant asthma (ATA) and 222 normal health controls (NC).

RESULTS: A significant difference in the genotype frequencies of FCER1G-237A>G was detected between AIA and ATA patients (p<0.05) both in co-dominant and recessive analysis models, whereas no significant relationships were identified between the frequencies of the other five single-nucleotide polymorphisms and AIA, ATA, and NC subjects. In addition, AIA patients carrying the homozygous AA genotype of FCER1G-237A>G exhibited significantly higher total serum IgE levels than did those with the GG/AG genotype (p=0.012). AIA patients expressing the CT/TT genotype at FCERIA-344C>T showed a higher prevalence of serum IgE specific to Staphylococcal enterotoxin A than did those with the CC genotype (p=0.008).

CONCLUSION: The FCER1G-237A>G and FCERIA-344C>T polymorphisms may contribute to the development of AIA in a Korean population.
MeSH terms
AdultAnti-Inflammatory Agents, Non-Steroidal/adverse effects*Antibodies, Bacterial/bloodAspirin/adverse effects*Asthma/chemically inducedAsthma/genetics*Asthma/immunologyAsthma/physiopathologyBronchial Provocation Tests/methodsCase-Control StudiesFemaleForced Expiratory VolumeGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansImmunoglobulin E/bloodMaleMiddle AgedPolymorphism, Single Nucleotide*Receptors, IgE/genetics*Superantigens/immunology
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > Research Organization > Regional Clinical Trial Center
AJOU Authors
김, 승현예, 영민박, 해심
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