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Comprehensive staging surgery including complete pelvic and para-aortic lymphadenectomy followed by adjuvant vaginal brachytherapy improves survival rates for intermediate-risk endometrial cancer patients

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dc.contributor.authorKong, TW-
dc.contributor.authorPaek, J-
dc.contributor.authorChang, SJ-
dc.contributor.authorChun, M-
dc.contributor.authorChang, KH-
dc.contributor.authorRyu, HS-
dc.date.accessioned2013-04-29T01:27:04Z-
dc.date.available2013-04-29T01:27:04Z-
dc.date.issued2012-
dc.identifier.issn0378-7346-
dc.identifier.urihttp://repository.ajou.ac.kr/handle/201003/8042-
dc.description.abstractAIM: To investigate the survival of patients with intermediate-risk endometrial cancer treated with comprehensive staging surgery including complete pelvic and para-aortic lymphadenectomy and adjuvant vaginal brachytherapy (VBT).



METHODS: Between January 2000 and December 2009, we retrospectively reviewed the medical records of 156 patients who underwent comprehensive surgical staging consisting of total hysterectomy, adnexectomy, peritoneal cytology, and complete pelvic/para-aortic lymphadenectomy. There were 122 low-risk and 34 intermediate-risk patients, and intermediate-risk patients received adjuvant VBT.



RESULTS: During the follow-up period, 7 (4.5%) of the 156 patients developed recurrent disease: 3 (2.5%) of the 122 low-risk and 4 (11.8%) of the 34 intermediate-risk patients. Among the 7 patients with recurrent disease, only 1 intermediate-risk patient died of disease and 6 stayed alive for the rest of the follow-up period. Disease-free survival at 5 years was 95.7% in the low-risk patients and 81.6% in the intermediate-risk patients, and this difference was statistically significant (p = 0.009). There was no statistically significant difference in overall survival at 5 years between the two groups (100% in low-risk patients vs. 96.7% in intermediate-risk patients, p = 0.061). Overall, grade 3 toxicities were seen in 1 (2.9%) patient.



CONCLUSION: Comprehensive staging surgery including complete pelvic and para-aortic lymphadenectomy followed by adjuvant VBT improves survival rates for intermediate-risk endometrial cancer patients, which are comparable with those of low-risk patients.
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dc.language.isoen-
dc.subject.MESHAdenocarcinoma-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBrachytherapy-
dc.subject.MESHEndometrial Neoplasms-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLymph Node Excision-
dc.subject.MESHMiddle Aged-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk-
dc.subject.MESHSeverity of Illness Index-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHVagina-
dc.titleComprehensive staging surgery including complete pelvic and para-aortic lymphadenectomy followed by adjuvant vaginal brachytherapy improves survival rates for intermediate-risk endometrial cancer patients-
dc.typeArticle-
dc.identifier.pmid22571964-
dc.identifier.urlhttp://www.karger.com/?DOI=10.1159/000336771-
dc.contributor.affiliatedAuthor공, 태욱-
dc.contributor.affiliatedAuthor백, 지흠-
dc.contributor.affiliatedAuthor장, 석준-
dc.contributor.affiliatedAuthor전, 미선-
dc.contributor.affiliatedAuthor장, 기홍-
dc.contributor.affiliatedAuthor유, 희석-
dc.type.localJournal Papers-
dc.identifier.doi10.1159/000336771-
dc.citation.titleGynecologic and obstetric investigation-
dc.citation.volume74-
dc.citation.number1-
dc.citation.date2012-
dc.citation.startPage68-
dc.citation.endPage75-
dc.identifier.bibliographicCitationGynecologic and obstetric investigation, 74(1). : 68-75, 2012-
dc.identifier.eissn1423-002X-
dc.relation.journalidJ003787346-
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Obstetrics & Gynecology
Journal Papers > School of Medicine / Graduate School of Medicine > Radiation Oncology
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Humanities & Social Medicine
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