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Limited maximal flow rate of target-controlled remifentanil infusion and induced cough

Authors
Min, SK; Kim, DH; Cho, HB; Moon, BK; Kim, JY
Citation
Anaesthesia, 67(2):145-148, 2012
Journal Title
Anaesthesia
ISSN
0003-24091365-2044
Abstract
This study evaluated the effect of limiting maximal infusion-pump flow rate on suppression of remifentanil-induced cough during target-controlled infusion. Two hundred and ten patients were randomly assigned to receive remifentanil at an effect-site concentration of 4.0 ng.ml(-1) with maximal flow rate limited to 100 (group R(100)), 200 (group R(200)), or 1200 ml.h(-1) (group R(1200)). The number of episodes of cough were recorded and graded as mild (1-2), moderate (3-4), or severe (5 or more). The incidence of cough was 2.9% in group R(100), 5.7% in group R(200) and 25.7% in group R(1200). Patients in group R(100) and R(200) had a significantly lower incidence of cough than those in group R(1200) (p < 0.05). Zero, two and five patients coughed a moderate amount in groups R(100), R(200) and group R(1200), respectively (p < 0.05). Limiting maximal infusion rate during remifentanil TCI suppressed remifentanil-induced cough.
MeSH terms
AdolescentAdultAgedAnalgesics, Opioid/*administration & dosage/*adverse effects/therapeutic useAntitussive Agents/*administration & dosage/*adverse effects/therapeutic useCough/*chemically induced/epidemiologyDrug Delivery SystemsFemaleHumansInfusion PumpsInfusions, IntravenousMaleMiddle AgedPain, Postoperative/complications/drug therapyPiperidines/*administration & dosage/*adverse effects/therapeutic useYoung Adult
DOI
10.1111/j.1365-2044.2011.06961.x
PMID
22251106
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Anesthesiology & Pain Medicine
AJOU Authors
민, 상기김, 대희조, 한범문, 봉기김, 종엽
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