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LPS induces melanogenesis through p38 MAPK activation in human melanocytes.

Authors
Ahn, JH; Jin, SH; Kang, HY
Citation
Archives of dermatological research, 300(6):325-329, 2008
Journal Title
Archives of dermatological research
ISSN
0340-36961432-069X
Abstract
We have observed that lipopolysaccharide (LPS) induces pigmentation in melanocytes and in this study have examined whether these responses are mediated by the p38 mitogen-activated protein kinase (MAPK) signaling pathway. LPS appears to stimulate the pigmentation of melanocytes and cultured skin. LPS was found to induce the expression of microphthalmia-associated transcription factor (MITF) and tyrosinase protein in cells. Stimulation of melanocytes with LPS led to time dependent phosphorylation of p38 MAPK. Furthermore, p38 MAPK functionally regulated the LPS-induced melanin formation in melanocytes; a p38 MAPK inhibitor, SB203580, almost completely attenuated the LPS-mediated up-regulation of melanin synthesis and induction of MITF and tyrosinase expression. These findings indicate that activation of p38 MAPK plays an important role in LPS-induced melanogenesis by up-regulating MITF and tyrosinase expression.
MeSH terms
Cell Differentiation/drug effectsCell Lineage/drug effectsCells, CulturedFemaleHumansImidazoles/pharmacologyLipopolysaccharides/pharmacology*MAP Kinase Signaling System/drug effectsMAP Kinase Signaling System/geneticsMAP Kinase Signaling System/immunologyMaleMelanins/antagonists & inhibitorsMelanins/biosynthesis*Melanocytes/cytologyMelanocytes/immunologyMelanocytes/metabolism*Microphthalmia-Associated Transcription Factor/antagonists & inhibitorsMicrophthalmia-Associated Transcription Factor/biosynthesis*Monophenol Monooxygenase/antagonists & inhibitorsMonophenol Monooxygenase/biosynthesis*Pyridines/pharmacologySkin Pigmentation/drug effectsTranscriptional Activationp38 Mitogen-Activated Protein Kinases/antagonists & inhibitorsp38 Mitogen-Activated Protein Kinases/genetics*p38 Mitogen-Activated Protein Kinases/immunology
DOI
10.1007/s00403-008-0863-0
PMID
18478240
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
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