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Cadmium-induced E-cadherin Expression in Cerebrovascular Endothelial Cells

Other Title
카드뮴이 뇌혈관 내피세포에서의 E-cadherin 발현에 미치는 영향
Authors
석, 선미 | 이, 태구 | 김, 영채 | 문, 창현  | 백, 은주  | 정, 이숙  | 이, 수환
Citation
Journal of environmental toxicology, 22(2). : 137-145, 2007
Journal Title
Journal of environmental toxicology
ISSN
1226-9158
Abstract
The effect of cadmium chloride on the expression of E-cadherin was examined in bEnd.3 mouse brain endothelial cells. induced release, which were blocked by non-steroidal antinflamatory drugs (NSAIDs) such as indomethacin and NS398 indicating the expression of COX-2 might contribute to production. decreased the expression of E-cadherin, but not VE-cadherin at levels of mRNA and protein. Reduced expression level of E-cadherin was restored by NSAIDs, which was reversed by the addition of . -induced decrease of E-cadherin level was also recovered by antioxidants including N-acetylcyteine (NAC) and trolox. Together with previous report which showed induced COX-2 expression in a cellular oxidative stress dependent manner, these data suggest that decreases E-cadherin expression through induction of cellular oxidative stress and in turn COX-2 expression in brain endothelial cells.
Keywords

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Physiology
Ajou Authors
문, 창현  |  백, 은주  |  이, 수환  |  정, 이숙
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