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Adverse Drug Reactions in Elderly Inpatients: Comparison with Younger Patients

Other Title
노인 입원환자에서 발생한 약물유해반응의 특성
Authors
김, 정은  | 견, 진옥 | 진, 선민 | 이, 영희 | 김, 주희  | 이, 현영 | 박, 해심  | 최, 영화  | 예, 영민
Citation
Korean journal of asthma, allergy and clinical immunology, 30(3). : 216-221, 2010
Journal Title
Korean journal of asthma, allergy and clinical immunology
ISSN
1226-8739
Abstract
Background: There have been few reports on the characteristics of adverse drug reactions (ADRs) in elderly patients among the Korean population.
Objective: To investigate the characteristics of ADRs in elderly patients compared with those in younger ones.
Method: ADRs were collected from a spontaneous reporting system at our university hospital in 2008. Characteristics including underlying diseases, duration of hospitalization, clinical manifestations, culprit drugs and number of concomitant medications were compared between the young (<65 years) and elderly (≥65 years) groups.
Result: A total of 528 ADRs occurred in 513 patients, and 120 ADRs (22.7%) occurred in 116 elderly patients. Their mean age was 71.6 years. Antibiotics (45.8%) were the most common culprit drugs. The prevalence of ADRs due to cardiovascular drugs was significantly higher in the elderly group (9.2%) than in the young group (2.9%, P=0.003). The most prevalent clinical types were skin manifestations (40.5%), gastrointestinal abnormalities (28.4%) and systemic reactions (23.5%) in both groups. Renal function abnormalities were significantly more prevalent in the elderly group (4.2%) than in the young group (0.5%, P=0.008). The mean number of concomitant medications was significantly higher in the elderly group (6.5±4.6) than in the young group (1.9±3.9).
Conclusion: For the early detection of ADRs in elderly patients, close monitoring of cardiovascular drug use and renal function are recommended.
Keywords

Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
Journal Papers > School of Medicine / Graduate School of Medicine > Infectious Diseases
Ajou Authors
김, 정은  |  김, 주희  |  박, 해심  |  예, 영민  |  최, 영화
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