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Effect of a Long-term, Oral Fixed Dose with a Combination of Aledronate and Cacitriol on the Cancellous Bone Microarchitecture in Ovariectomized Rats

Other Title
Alendronate와 Calcitriol 고정용량복합제의 장기간의 복용이 난소가 제거된 백서의 해면골의 미세구조에 미치는 효과
Authors
Ji, HM; Nair, SG; Won, YY; Kim, J; Son, MA
Citation
Taehan Chŏnghyŏng Oekwa Yŏn'gu Hakhoe chi, 14(1):24-32, 2011
Journal Title
Taehan Chŏnghyŏng Oekwa Yŏn'gu Hakhoe chi; Journal of Korean Orthopaedic Research Society; 대한정형외과연구학회지
ISSN
1226-8933
Abstract
Purpose: To study the effect of a long-term, oral, fixed dose with a combination of alendronate and calcitriol on the cancellous bone microarchitecture in an ovariectomized rat model.



Materials and Methods: Twenty eight female Sprague-Dawley rats were divided into 2 equal groups: a non-medication group (OVX), and a medication group (ALD). The ALD group was treated with an oral daily fixed dose with a combination of alendronate and calcitriol for six months, starting from 4 weeks after ovariectomy, while the OVX group was given only a placebo. After six months, all animals were sacrificed, and an in vitro micro-CT analysis of the the distal femur was performed. The bone volume fraction (BV/TV), trabecular thickness (Tb.Th), trabecular separation (Tb.Sp), trabecular number (Tb.N), structure model index (SMI), connectivity density (Conn.D), and bone mineral density (BMD) were assessed.



Results: The ALD group had significantly higher BV/TV, Tb N, BMD and Conn.D and it also had significantly lower Tb Sp and SMI than the OVX group.



Conclusion: A long term, daily, oral fixed dose with a combination of alendronate and calcitriol could significantly reduce the osteoporotic changes in this ovariectomized rat model.
Keywords
MicroarchitectureCancellous boneOvariectomized ratAlendronateCalcitriolLong-termOralCombination
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Orthopedic Surgery
AJOU Authors
지, 형민원, 예연
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