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Current Treatment Strategies for Castration-Resistant Prostate Cancer

Authors
Kim, SJ; Kim, SI
Citation
Korean journal of urology, 52(3):157-165, 2011
Journal Title
Korean journal of urology
ISSN
2005-67372005-6745
Abstract
Prostate cancer is the most common cancer in men in United States and the fifth most common cancer in men in Korea. Although the majority of patients with metastatic prostate cancer initially respond to androgen deprivation therapy, almost all patients will eventually progress to develop castration-resistant prostate cancer (CRPC). Treatment options for CRPC remain limited. Prostate cancer was considered unresponsive to chemotherapy until the mid-1990s, when mitoxantrone combined with prednisone was shown to play a role in the palliative treatment of patients with CRPC. In 2004, two large randomized clinical trials demonstrated for the first time a small but significant survival advantage of docetaxel-based chemotherapy compared with mitoxantrone in patients with metastatic CRPC. Recently, cabazitaxel was shown to improve survival in patients with metastatic CRPC who progressed after docetaxel-based chemotherapy. Sipuleucel-T was also demonstrated to improve overall survival in patients with asymptomatic or minimally symptomatic metastatic CRPC. Along with mitoxantrone and docetaxel, cabazitaxel and sipuleucel-T are now approved for use in metastatic CRPC by the US Food and Drug Administration. There have been multiple early-phase clinical trials of various agents for the treatment of CRPC, and some are in phase III development. This review focuses on the key clinical trials of various treatment options of CRPC currently in use and under investigation.
Keywords
Drug therapyImmunotherapyMolecular targeted therapyProstatic neoplasmsSurvival
DOI
10.4111/kju.2011.52.3.157
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
AJOU Authors
김, 세중김, 선일
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