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Evaluation of Respiratory Parameters in Patients with Acute Lung Injury Receiving Adaptive Support Ventilation

Other Title
급성 폐손상 환자에서 Adaptive Support Ventilation 적용 시 호흡지표의 양상
Authors
이, 규성; 정, 우영; 정, 윤정; 박, 주헌; 신, 승수; 황, 성철; 박, 광주
Citation
Tuberculosis and respiratory diseases, 70(1):36-42, 2011
Journal Title
Tuberculosis and respiratory diseases
ISSN
1738-35362005-6184
Abstract
Background: Adaptive support ventilation (ASV), an automated closed-loop ventilation mode, adapts to the mechanical characteristics of the respiratory system by continuous measurement and adjustment of the respiratory parameters. The adequacy of ASV was evaluated in the patients with acute lung injury (ALI).



Methods: A total of 36 patients (19 normal lungs and 17 ALIs) were enrolled. The patients’ breathing patterns and respiratory mechanics parameters were recorded under the passive ventilation using the ASV mode.



Results: The ALI patients showed lower tidal volumes and higher respiratory rates (RR) compared to patients with normal lungs (7.1±0.9 mL/kg vs. 8.6±1.3 mL/kg IBW; 19.7±4.8 b/min vs. 14.6±4.6 b/min; p<0.05, respectively). The expiratory time constant (RCe) was lower in ALI patients than in those with normal lungs, and the expiratory time/RCe was maintained above 3 in both groups. In all patients, RR was correlated with RCe and peak inspiratory flow (rs=-0.40; rs=0.43; p<0.05, respectively). In ALI patients, significant correlations were found between RR and RCe (rs=-0.76, p<0.01), peak inspiratory flow and RR (rs=-0.53, p<0.05), and RCe and peak inspiratory flow (rs=-0.53, p<0.05).



Conslusion: ASV was found to operate adequately according to the respiratory mechanical characteristics in the ALI patients. Discrepancies with the ARDS Network recommendations, such as a somewhat higher tidal volume, have yet to be addressed in further studies.
Keywords
Acute Lung InjuryRespiratory MechanicsVentilatorsMechanicalAutomationVentilator-Induced Lung Injury
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Medical Science
Journal Papers > School of Medicine / Graduate School of Medicine > Pulmonary & Critical Care Medicine
AJOU Authors
이, 규성정, 우영정, 윤정박, 주헌신, 승수황, 성철박, 광주
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