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The Role of C-Kit Receptor Level as a Serological Marker for Predicting the Extent of Upper and Lower Airway Inflammation in Patients Sensitized to House Dust Mites

Other Title
집먼지진드기에 감작된 알레르기성 천식과 비염 환자에서 기도 염증 정도의 예측 인자로서의 혈청 c-kit 수용체의 역할
Authors
유, 혜수; 김, 주희; 황, 의경; 남, 영희; 진, 현정; 신, 유섭; 예, 영민; 남, 동호; 박, 해심
Citation
Chʿŏnsik mit alrerugi, 32(2):92-100, 2012
Journal Title
Chʿŏnsik mit alrerugi; Journal of asthma, allergy and clinical immunology; Korean journal of asthma, allergy and clinical immunology; 천식 및 알레르기
ISSN
1226-8739
Abstract
Background: Allergic rhinitis can progress to asthma. Both allergic rhinitis and asthma are characterized by Th2-dependent inflammation due to activated mast cells and eosinophils. Mast cells are dependent on kit-mediated activation, and the stem cell factor (SCF)/c-kit pathway leads to eosinophil infiltration. We investigated whether inflammation through the SCF/c-kit pathway would be associated with upper and lower airway inflammation.



Methods: We enrolled 71 allergic asthma patients with rhinitis (group I) and 47 patients with allergic rhinitis alone (group II), and 59 non-atopic healthy controls (group III). Groups I and II showed positive responses to house dust mites in skin prick tests. The serum concentrations of c-kit receptor and SCF were measured by using ELISA. Eosinophil cationic protein (ECP) levels were measured by using the CAP system. Other clinical parameters were analyzed.



Results: There were significant differences in the mean values of c-kit receptor levels between the 3 groups (117.27± 41.05 vs. 93.13±37.21 vs. 88.45±24.32 ng/mL, P<0.001). The c-kit receptor level was the highest in group I. However, no significant differences were found in SCF levels between the 3 groups. A positive correlation was found between c-kit receptor and ECP levels in groups I and II (r=0.31, P=0.016). Moreover, a positive correlation was found between c-kit receptor levels and total eosinophil counts in groups I and II (r=0.34, P<0.001). However, there were no significant associations between c-kit receptor levels and clinical parameters, such as forced expiratory volume 1% predicted value in group I.



Conclusion: Serum c-kit receptor levels can be a useful serologic marker for predicting the extent of eosinophilic inflammation in upper and lower airway inflammation.
Keywords
Proto-oncogene protein c kitAsthmaRhinitis
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Allergy
AJOU Authors
유, 혜수신, 유섭예, 영민남, 동호박, 해심
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