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The prognostic significance of growth factors and growth factor receptors in gastric adenocarcinoma.

Authors
Kim, JY; Jeon, TJ; Bae, BN; Kwon, JE; Kim, HJ; Park, K; Shin, E
Citation
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica, 121(2):95-104, 2013
Journal Title
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
ISSN
0903-46411600-0463
Abstract
We evaluated growth factors/receptors expression in gastric adenocarcinoma. Immunohistochemistry was used to evaluate epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), VEGF-D, VEGF receptor (VEGFR)-2, VEGFR-3, transforming growth factor (TGF)-α, TGF-β1, and TGF-β-RII in tissue microarrays of adenocarcinoma, dysplasia, metaplasia, and gastritis. In adenocarcinoma, the expression rates of EGFR, VEGF, VEGF-D, VEGFR-2, VEGFR-3, TGF-α, TGF-β1, and TGF-β-RII were 2.0%, 0%, 10.7%, 4.4%, 11.2%, 26.3%, 9.4%, and 19.5%, respectively. VEGF-D, TGF-α, TGF-β1, and TGF-β-RII expression rate were higher in adenocarcinoma than in other groups. TGF-β-RII expression was correlated with VEGFR-3, VEGF-D, and TGF-α expression in adenocarcinomas. Tumor location, histologic type, stage, lymphatic invasion, perineural invasion, angioinvasion, VEGF-D, and VEGFR-2 expressions were associated with patient survival in a log rank test and advanced stage and positive expression of VEGF-D were poor prognostic factors using Cox analysis. VEGF-D expression may be of prognostic value in gastric adenocarcinoma, whereas EGFR and TGF family expression may only have a minor influence.
MeSH terms
Cloning, MolecularFemaleGene ExpressionHumansImmunohistochemistryMaleMiddle AgedPrognosisProportional Hazards ModelsProtein-Serine-Threonine Kinases/genetics/metabolismReceptor, Epidermal Growth Factor/genetics/metabolismReceptors, Transforming Growth Factor beta/genetics/metabolismRetrospective StudiesStomach Neoplasms/*diagnosis/metabolism/*pathologyTissue Array AnalysisTransforming Growth Factor beta1/genetics/metabolismTumor Markers, Biological/genetics/metabolismVascular Endothelial Growth Factor D/*genetics/metabolismVascular Endothelial Growth Factor Receptor-2/*genetics/metabolismVascular Endothelial Growth Factor Receptor-3/*genetics/metabolism
DOI
10.1111/j.1600-0463.2012.02942.x
PMID
23030255
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
권, 지은
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