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The expression of metabolism-related proteins in phyllodes tumors.

Authors
Kwon, JE; Jung, WH; Koo, JS
Citation
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 34(1):115-124, 2013
Journal Title
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
ISSN
1010-42831423-0380
Abstract
The purpose of this study was to investigate the association between the expression of hypoxia-inducible factor (HIF)-1α, insulin-like growth factor (IGF)-1, glucose transporter 1 (Glut-1), carbonic anhydrase IX (CAIX), and monocarboxylate transporter (MCT)4, which are metabolism-related proteins in phyllodes tumors (PTs), and clinicopathologic factors and its implication. We used tissue microarrays to analyze 207 PTs and performed immunohistochemical staining against the glycolysis-related molecules HIF-1α, IGF-1, Glut-1, CAIX, and MCT4. We then compared the immunohistochemical results and clinicopathologic parameters. The expressions of HIF-1α, Glut-1, CAIX, and MCT4 in the stromal component of PTs increased (P = 0.019, P < 0.001, P = 0.045, and P < 0.001, respectively) with increasing tumor grade. According to univariate analysis, factors associated with shorter disease-free survival were Glut-1 expression (P = 0.001) and MCT4 expression (P < 0.001) in the stromal component, and the factors associated with shorter overall survival were IGF-1 expression (P = 0.012), Glut-1 expression (P < 0.001), CAIX expression (P = 0.039), and MCT4 expression (P < 0.001) in the stromal component. Our investigation of stromal expression of the metabolism-related proteins HIF-1α, IGF-1, Glut-1, CAIX, and MCT4 revealed that, as the PT grade increased, the stromal expression of HIF-1α, Glut-1, CAIX, and MCT4 significantly increased. This result suggested that increasing PT grade is associated with increased glycolysis in the stromal component.
MeSH terms
AdultAntigens, Neoplasm/metabolismBreast Neoplasms/*metabolism/mortalityCarbonic Anhydrases/metabolismDisease-Free Survival*Energy MetabolismFemaleGlucose Transporter Type 1/metabolismGlycolysisHumansHypoxia-Inducible Factor 1, alpha Subunit/metabolismInsulin-Like Growth Factor I/metabolismMonocarboxylic Acid Transporters/metabolismMuscle Proteins/metabolismNeoplasm GradingPhyllodes Tumor/*metabolismSurvivalTumor Markers, Biological/metabolism
DOI
10.1007/s13277-012-0518-9
PMID
22986897
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
권, 지은
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