99 347

Cited 12 times in

Association of polymorphism in MicroRNA 219-1 with clearance of hepatitis B virus infection.

Authors
Cheong, JY; Shin, HD; Kim, YJ; Cho, SW
Citation
Journal of medical virology, 85(5):808-814, 2013
Journal Title
Journal of medical virology
ISSN
0146-66151096-9071
Abstract
Polymorphisms in the primary microRNA region may be associated with natural course of hepatitis B virus (HBV) infection. This study evaluated if the mircoRNA 219-1 (miR-219-1) polymorphism can influence the susceptibility towards persistence of HBV infection and the progression to hepatocellular carcinoma (HCC) in patients with chronic HBV infection. A total of 1,439 individuals having either past or present evidence of HBV infection were enrolled for the study. The subjects were divided into four groups; (1) spontaneous recovery (n = 404), (2) chronic HBV carrier (n = 313), (3) chronic HBV carrier with cirrhosis (n = 305), and (4) hepatocellular carcinoma (n = 417). Genotyping was performed at three polymorphic variants (rs421446, rs107822, and rs213210) in the pri-miRNA region of miR-219-1. The rs421446 T allele was found to be strongly associated with HBV clearance (OR = 0.73, P = 0.0005 in a codominant model and OR = 0.67, P = 0.0009 in a dominant model, OR = 0.69, P = 0.04 in a recessive model, respectively). The rs107822 G allele was also found to be associated with HBV clearance (OR = 0.79, P = 0.008 in a codominant model and OR = 0.72, P = 0.01 in a dominant model, respectively). In haplotype analysis, ht2 (T-G-T) and ht1 (C-A-C) were found to be in significant association with the clearance of HBV. However, no significant association was observed between miR-219-1 polymorphism and the risk of HCC occurrence. This result suggests that polymorphisms in the pri-miRNA region of miR-219-1 might be a genetic factor for HBV clearance after infection.
MeSH terms
AdolescentAdultAgedAged, 80 and overCarcinoma, Hepatocellular/genetics/immunology/virologyCarrier State/immunology/virologyCase-Control StudiesFemaleHepatitis B/complications/*genetics/*immunology/virologyHepatitis B virus/*immunologyHumansLiver Cirrhosis/complications/genetics/immunology/virologyLiver Neoplasms/genetics/immunology/virologyMaleMicroRNAs/*genetics/*immunologyMiddle Aged*Polymorphism, GeneticYoung Adult
DOI
10.1002/jmv.23551
PMID
23508906
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Gastroenterology
AJOU Authors
정, 재연조, 성원
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

해당 아이템을 이메일로 공유하기 원하시면 인증을 거치시기 바랍니다.

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse