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Impact of caveolin-1 expression on the prognosis of transitional cell carcinoma of the upper urinary tract.

Authors
Cho, DS; Yim, H; Cho, KS; Hong, SJ; Cho, NH; Kim, SI; Ahn, HS; Kim, SJ
Citation
Journal of Korean medical science, 23(2):296-301, 2008
Journal Title
Journal of Korean medical science
ISSN
1011-89341598-6357
Abstract
This study aimed to investigate the relationship of caveolin-1 expression with prognosis in patients with transitional cell carcinoma of the upper urinary tract (TCCUUT). Formalin-fixed, paraffin-embedded tissue sections of TCC-UUT from 98 patients, who had undergone radical nephroureterectomy, were stained immunohistochemically using antibodies against caveolin-1. The expression pattern of caveolin- 1 was compared with the clinicopathological variables. The caveolin-1 expression was significantly correlated with T stage (p<0.001) and grade (p=0.036). The survival rate of patients with caveolin-1 positive tumors was significantly lower than that of patients with caveolin-1 negative tumors (p<0.0001). The univariate analyses identified T stage, grade, and caveolin-1 expression as significant prognostic factors for cancer-specific survival, whereas the multivariate analyses indicated that T stage and caveolin-1 expression were independent prognostic factors. These results show that the increased expression of caveolin-1 is associated with tumor progression and poor prognosis in TCC-UUT, suggesting that caveolin-1 may play an important role in the progression of TCC-UUT.
MeSH terms
AdultAgedAged, 80 and overCarcinoma, Transitional Cell/diagnosis*Carcinoma, Transitional Cell/metabolism*Caveolin 1/biosynthesis*Disease ProgressionDisease-Free SurvivalFemaleGene Expression ProfilingGene Expression Regulation, Neoplastic*HumansMaleMiddle AgedPrognosisUrologic Neoplasms/diagnosis*Urologic Neoplasms/metabolism*
DOI
10.3346/jkms.2008.23.2.296
PMID
18437015
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Urology
Journal Papers > School of Medicine / Graduate School of Medicine > Pathology
AJOU Authors
임, 현이김, 선일안, 현수김, 세중
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