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Increased blood flow and vasculature in solar lentigo

Authors
Hasegawa, K | Fujiwara, R | Sato, K | Park, JY | Kim, SJ | Kim, M  | Kang, HY
Citation
The Journal of dermatology, 43(10). : 1209-1213, 2016
Journal Title
The Journal of dermatology
ISSN
0385-24071346-8138
Abstract
Solar lentigo (SL) is a hallmark of ultraviolet (UV)-induced photoaged skin and growing evidence implicates blood vessels in UV-associated pigmentation. In this study, we investigated whether the vasculatures are modified in SL. Twenty-five women with facial SL were enrolled and colorimetric and blood flow studies were performed. There was a significant increase in erythema which was associated with increased blood flow in the lesional skin compared with perilesional normal skin. Immunohistochemical studies with 24 facial SL biopsies consistently revealed a significant increase in vessel density accompanied by increased levels of vascular endothelial growth factor expression. CD68 immunoreactivity was significantly higher in lesional skin suggesting increased macrophage infiltration in SL. In conclusion, SL is characterized by increased blood flow and vasculature. These findings suggest the possible influence of the characteristics of vasculature on development of SL.
MeSH

DOI
10.1111/1346-8138.13458
PMID
27238145
Appears in Collections:
Journal Papers > School of Medicine / Graduate School of Medicine > Dermatology
Ajou Authors
강, 희영  |  김, 미선
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